IDENTIFICATION AND CHARACTERIZATION OF SODIUM AND CHLORIDE-DEPENDENT GAMMA-AMINOBUTYRIC ACID (GABA) TRANSPORTERS IN EUKARYOTIC PATHOGENS

Mr Otarigho Benson and Mofolusho O. Falade   (Published 2017)

Mr Benson
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INTRODUCTION

Infectious diseases such as malaria, trypanosomiasis, leishmaniasis, schistosomiasis have huge health, social and economic impact on major populations particularly in endemic regions (Parsons et al., 2015). They are responsible for a high degree of morbidity and mortality. Globally, about 50% of deaths attributed to these diseases occur among the poorest countries of the world (Fuller et al., 2015). In addition, some of these pathogens infect domestic and wild animals, consequently, leading to zoonotic infections (Cook, 2015). Although several drugs have been developed against most of these infectious diseases, there are emergence of resistant strains for some and a lack of vaccines for most of these parasites particularly the most economically important ones (Pundir et al., 2015). Therefore, there is a necessity to develop new drugs, identify novel drug targets to help in control efforts (Steinbiss et al., 2016). The genomic sequences of parasitic diseases are rapidly becoming available with the promise of the identification of new drug targets and novel chemotherapeutic treatments for the control of parasitic diseases. One of such targets is GABA transporter that is the main inhibitory neurotransmitter belong to a family of neurotransmitter:sodium symporters (Comitani, et al., 2016; Ecker et al., 2017). Hence, the aim of this work is to identify, characterize and analyse sodium and chloride-dependent gamma-aminobutyric acid (GABA) transporters of eukaryotic pathogens from microbe genomes.

Item Type: Conference presentation
Format: PPT presentation,   3.62 MB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: Sodium and Chloride-dependent Gamma-aminobutyric Acid (GABA)
Department: Natural Science
Field of Study: Biology
Uploaded By: Uddin Osemengbe Oyaimare
Date Added: 01 Nov 2017 12:07pm
Last Modified: 27 Nov 2017
conference URL: https://www.edouniversity.edu.ng/oer/conference/identification_and_characterization_of_sodium_and_chloride-dependent_gamma-aminobutyric_acid_gaba_transporters_in_eukaryotic_pathogens


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