SYNERGISTIC, ATTENUATIVE AND MODULATORY ACTIVITY IN DIMETHYLNITROSAMINE (DMN)-INDUCED FIBROTIC RATS TREATED WITH VERNONIA AMYGDALINA AND ANNONA MURICATA LEAVES

Prof Usunobun Usunomena   (Published 2019)

Prof Usunomena
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INTRODUCTION
• Dimethylnitrosamine (DMN), a member of Nitrosamine family
is generated from the in situ reaction of dimethylamine
(DMA) with monochloroamine in the disinfection process or
the nitrosation of DMA by nitrite (Gerecke and Sedlak, 2003).
• DMN is a potent hepatotoxin, carcinogen and mutagen which
exerts its carcinogenic effects, causes fibrosis, cirrhosis and
induces hepatic necrosis through metabolic activation by
CYP2E1 (George et al., 2001; Kasprzyk-Hordern et al., 2005).
• The occurrence of dietary and environmental chemicals such
as DMN in our drinks and foods including fish, meat as well as
fresh supermarket products is well established (Okafor and
Ogbonna, 2003; Okafor and Nwogbo, 2005; Okafor et
al., 2007, Griesenbeck, et al.,2009).

Item Type: Conference presentation
Format: PDF document,   1.19 MB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: BIOCHEMISTRY
Department: Natural Science
Field of Study: Biochemistry
Uploaded By: Uwaifo Ferdinand
Date Added: 04 Feb 2019 1:55pm
Last Modified: 04 Feb 2019
conference URL: https://www.edouniversity.edu.ng/oer/conference/synergistic_attenuative_and_modulatory_activity_in_dimethylnitrosamine_dmn-induced_fibrotic_rats_treated_with_vernonia_amygdalina_and_annona_muricata_leaves


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