ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF HIBISCUS SABDARIFFA ON CARRAGEENAN INDUCED INFLAMMATION IN WISTAR RAT

Dr Olaniyan Olugbemi Tope and Meraiyebu A.B1,Eneze C1, Anjorin Y.D3, Dare J.B2   (Published 2019)

Dr Olugbemi Tope
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Abstract

ABSTRACT:
Background: Hibiscus sabdariffa is used for medicinal purposes, especially in alternative medicine. It
is a folk remedy for abscesses, cancer, cough, debility, dyspepsia, dysuria, fever, hangover, heart ailments,
neurosis, scurvy and strangury. This present study was carried out to investigate the anti-inflammatory activity
of methanolic extract of hibiscus sabdariffa in adult wistar rat.
Methods: A total of Twenty-five (25) of both sexes rats weighing between 180 - 200 g were randomly
divided into five (5) groups of five (5) animals each. Group 1 received only 1 ml distilled water which served as
control. Group 2 were induced with inflammation using (0.1ml/kg b.w) carrageenan without treatment while
Group 3 and 4 were induce with inflammation and treated with low dose (250 mg/kg b.w) and high dose (500
mg/kg b.w) of extract of hibiscus sabdariffa respectively. Group 5 served as the positive control group, they
were treated with (20mg/kg b.w) diclofenac after carrageenan induced inflammation. The paw diameter of each
rat was measured before and after the inflammation then after treatment.
Results: There was significant reduction (p< 0.05) in paw diameter in the group that received high
dose (500 mg/kg b.w) of methanolic extract of hibiscus sabdariffa treated group from Mean±SEM of
0.566±0.023 to 0.414±0.009 as compared with the untreated group.
Conclusions: The decrease in paw diameter in the high dose group showed that methanolic extract of
hibiscus sabdariffa possess anti-inflammatory properties against carrageenan induced inflammation similar to
the action of diclofenac. The therapeutic effect of this extract will encourage its use in the treatment of
inflammation.


Item Type: Journal article(non-copyrighted)
Format: PDF document,   210.74 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: physiology
Department: Medicine and Surgery
Field of Study: Health and Society
Uploaded By: Uwaifo Ferdinand
Date Added: 06 Feb 2019 3:05pm
Last Modified: 06 Feb 2019
Journal URL: https://www.edouniversity.edu.ng/oer/journal/anti-inflammatory_activity_of_methanolic_extract_of_hibiscus_sabdariffa_on_carrageenan_induced_inflammation_in_wistar_rat


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