ANTIFERTILITY EFFECTS OF ETHANOLIC ROOT BARK EXTRACT OF CHRYSOPHYLLUM ALBIDUM IN MALE ALBINO RATS
Dr Idaguko Chika Anna and Onyeka CA1*, Aligwekwe AU1, Olawuyi TS1, Nwakanma AA1, Kalu EC1, Oyeyemi AW2 (Published 2018)
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Summary: The present study was conducted to investigate the antifertility activity of the ethanol root bark extract of Chrysophyllum albidum on sperm parameter and hormonal levels in rats. Eighteen male rats were divided into three groups of six animals each. The first group (A) received distilled water and served as control. The second and third group (B & C) of animals were administered the ethanol root bark extract daily at 100mg/kg body weight and 200mg/kg decrease in the caudal epididymal sperm count, motility and sperm morphology was observed compared with the control. Serum gonadotrophins and testosterone were measured and C. albidum extract also caused a dose related significant reduction (p<0.05) of serum testosterone, Luteinizing hormones and FSH concentrations in all treatment groups as compared to the control. The result showed that ethanol extract of the root bark of C. albidum suppresses the hormonal levels and sperm production in rats and deserves to be further investigated as a potential male contraceptive agent.
Industrial relevance: The unique advantages of this antifertility option is that they are safer, reliable, affordable, long-lasting, acceptable and can be taken without consulting a health worker in comparison to pharmaceutical drugs that are expensive and have negative side effect.
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 201.41 KB|
|Department:||Medicine and Surgery|
|Field of Study:||Medicine|
|Uploaded By:||Uwaifo Ferdinand|
|Date Added:||25 Mar 2019 10:20am|
|Last Modified:||25 Mar 2019|
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