ANTIHEPATOTOXIC EFFICACY OF VERNONIA AMYGDALINA ETHANOLIC LEAF EXTRACT ON DIMETHYLNITROSAMINE (DMN)-INDUCED LIVER DAMAGE IN RATS
Prof Usunobun Usunomena (Published 2014)
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Introduction: Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen and mutagen whose toxicity is mediated by its
reactive metabolites and not by the parent compound. The antihepatotoxic efficacy of ethanolic leaf extract of Vernonia
amygdalina against DMN-induced liver damage in rats thus, needs to be investigated.
Methodology: Rats were given DMN, at a single dose of 12 g/kg body weight orally on day 8 after pretreatment with 400mg/kg
Vernonia amygdalina for 7days and thereafter investigated for toxicity and hepatoprotection 48 hours later.
Result: DMN produced liver damage in rats as manifested by the significant rise (p?0.05) in serum levels of alanine
aminotransferase (ALT), total cholesterol (TC) and decrease in serum total protein (TP), globulin, albumin, white blood cells
(WBCs), red blood cells (RBCs), packed cell volume (PCV), platelets and hemoglobin (HB) levels compared to control.
However, Pretreatment of rats with ethanolic leaf extract of Vernonia amygdalina (400 mg/kg body weight) once daily for seven
days to DMN treated rats significantly attenuated (p?0.05) the toxicity by DMN.
Conclusion: Ethanolic leaf extracts of Vernonia amygdalina having antihepatotoxic properties minimized the deleterious effects
generated by the hepatotoxin, DMN, thereby suggesting its use as a potent antihepatotoxic agent
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 125.29 KB|
|Keywords:||Dimethylnitrosamine, Vernonia amygdalina, Antihepatotoxic, Hematological parameters|
|Field of Study:||Biochemistry|
|Uploaded By:||Imarhiagbe Odoligie|
|Date Added:||22 Nov 2017 12:10pm|
|Last Modified:||22 Nov 2017|
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