BLOOD SUBSTITUTES - A RELIABLE ALTERNATIVE? A REVIEW

Dr Nwagu Marcellinus Uchechukwu and Borke M.E; M.E. EnosoJease; M.U. Nwagu and S.O. Abegunde   (Published 2018)

Dr Marcellinus Uchechukwu
See Profile Page

Abstract

ABSTRACT
Background/Objective: In a rapidly developing world where conflicts are inevitable and accidents
and other forms of trauma are constantly encountered there is an increased need for blood transfusion
to keep victims ofthese events alive. As the need for blood increases, there is a corresponding decrease
in the amount of blood available for transfusion due to increased demand and a falling donor pool. In
addition, there are people who due to religious reasons abhor blood transfusion. The emergence ofthe
HIV epidemic has made blood transfusion a hazard especially in resource poor countries. In order to
meet these challenges there has been efforts to shift emphasis from blood transfusion to artificial blood
substitute. This review brings to the fore the available substitutes.
Methods: Literature on the subject was reviewed using manual library search, articles injoumals,
internet search and conference abstracts.
Results: Efforts to develop an alternative to blood has been going on in the past four decades and
various approaches have been used to see which ofthese compounds will meet the requirement for an
ideal blood substitute. The research has been spurred by many factors chief among which is the need
to meet the ever increasing demand for blood in the event of surgical procedures, trauma management
and those who detest blood transfusion. Great advances have been made and currently researchers
have developed up to third generation blood substitutes which have undergone clinical trails up to
Address for Correspondence:
Borke, M.E, Department ofHaematology and Blood Transfusion, Faculty of Clinical Medicine, Delta
State University, Abraka, Delta State, Nigeria. Email: monaborkeme@:;vahoo.com
35
THE NIGERIAN JOURNAL OF GENERAL PRACTICE - VOL. 08 NO. 04, NOVEMBER, 2009
phase three trials. It is hoped that in not too distant future these products will be avai Iable for routine
use, thus making blood donation irrelevant in the management of critically ill patients.


Item Type: Journal article(non-copyrighted)
Format: PDF document,   7.05 MB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: medicine
Department: Medicine and Surgery
Field of Study: Medicine
Uploaded By: Uwaifo Ferdinand
Date Added: 15 Mar 2019 2:26pm
Last Modified: 15 Mar 2019
Journal URL: https://www.edouniversity.edu.ng/oer/journal/blood_substitutes_-_a_reliable_alternative_a_review


Google Docs     Print     Download

If you love watching movies on your android phone, download moviebox pro apk for free

The MyCCPay has a super advanced Bank Statements with Program Fee for Visa on our Home Page to effortlessly increase Funds having Social Security number that get Customer Support Team from the United States before seeing Transaction History and their extra Benefits into Current Balance.