CD4+ CELL COUNT, LIPID AND LIPOPROTEIN LEVELS IN HIV PATIENTS ON DRUG TREATMENT
Prof Muhibi Musa Abidemi and Adedokun Kamoru A1,5*, Olisekodiaka Japhet M1,4, Adeyeye Adetunji D2, Adepeju Akinlawon A2, Muhibi Musa A3, Onifade Abdufatah A5, Olaoye Jelili A6, Adetoro Taofik A1, UGWU Prince I1,5, Oyenike Musiliu A1 (Published 2018)
See Profile Page
Background: Previous reports showed lack of consensus on the possible etiology of coronary artery disease (CAD) between
HIV-treatment with highly active antiretroviral therapy (HAART) and HIV-infection in particular. The aim of this
study was to find out correlations of HIV-treatment and HIV-infection with CAD risk.
Method: One hundred and twenty (120) participants involving HIV-patients on treatment (n = 40), treatment-naïve (n =
40) and equal number of age- and sex-matched controls were enrolled. The total cholesterol, triglycerides and lipoprotein
(HDL-C) were analyzed using spectrophotometry. The LDL-C was calculated using Friedewald equation, TC/HDL-C and
LDL-C/HDL-C ratios were also calculated. The CD4+ cell count was determined using flow cytometry.
Result: The mean plasma total cholesterol levels in patients’ groups on treatment and treatment-naïve were significantly
reduced when compared with controls, but the mean triglyceride levels for both treatment and the treatment-naïve groups
were significantly increased when compared with controls. However, HDL-C and LDL-C values for patients on HAART
and the treatment-naive were significantly reduced when compared with controls respectively. The CAD risk predictors,
LDL-c and TC/HDL-C ratio, were significantly increased in patients on HAART when compared with the treatment-naive.
The mean CD4+ cell count in treatment-naive was significantly lowered against both groups for treatment and controls.
Conclusion: In this present study, abnormal lipid profile was associated with both HIV-infection and HAART-treatment.
However, TC/HDL-C ratio, the strong predictor of CAD events in metabolic disorder was markedly high in HAARTtreatment
and the associated difference may threaten higher risk for cardiovascular disease (CVD) during treatment.
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 378.74 KB|
|Keywords:||MEDICAL LABORATORY SCIENCE|
|Department:||Medical Laboratory Science|
|Field of Study:||Medical Laboratory Science|
|Uploaded By:||Uwaifo Ferdinand|
|Date Added:||18 Mar 2019 7:59am|
|Last Modified:||18 Mar 2019|
Google Docs Print Download