ABSTRACT
PURPOSE: PMTCT interventions, especially initiation of Highly active antiretroviral therapy (HAART) has modified the
natural history of HIV infection by reducing both peripartal and neonatal HIV infections, but the pattern of the immunologic
responses of these pregnant women to HAART remains speculative. It is hoped from this study, to describe the pattern of
immunologic response of naïve, HIV positive pregnant women on their first initiation on HAART.
METHODS: This study described the pattern of CD4 changes observed in freshly diagnosed 126 HIV positive pregnant
women, stratified into the trimesters of pregnancy and commenced on HAART (Zidovudine, Lamivudine and Nevirapine) for
a period of 2 months in pregnancy. CD4 counts were determined at point of recruitment and monthly thereafter using a
Parteccytometer counter (Cyflow(R)). Neonatal outcome was also described.
RESULTS: Our findings suggest better immunologic response and fewer neonatal infectionsin group of naïve women
initiated on HAART while in the first 26 weeks of pregnancy and lesser response in those commenced in the third trimester
of pregnancy.
CONCLUSION: Concerted efforts should be directed towards the initiation of HAART prophylaxis before end of 2nd
trimester of pregnancy.