DIMETHYLNITROSAMINE (DMN) PRE-TREATED RATS AND PROTECTIVE EFFECT OF VERNONIA AMYGDALINA POST-TREATMENT ON LIVER FUNCTION
Prof Usunobun Usunomena and Anyanwu Gabriel O (Published 2016)
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Background: Liver disease and toxicity is common, especially with many drug treatments. The effect of Vernonia amygdalina ethanolic
leaf extract post-treatment on rats pre-treated with dimethylnitrosamine (DMN) was evaluated.
Methods: Male wistar rats were orally administered DMN (single dose of 25 mg/kg) on first day and thereafter post-treated with 100 and
200mg/kg ethanolic leaf extract of Vernonia amygdalina for seven days. Analysis of serum concentrations of albumin, total protein, total
bilirubin and glucose were carried out.
Results: Administration of DMN alone to rats significantly increased glucose and total bilirubin concentration (P < 0.05) in the serum
while it significantly reduced (P<0.05) serum total protein and albumin concentrations when compared with controls. However, post-treatment of DMN administered rats with 100 and 200 mg/kg ethanolic extract leaf of Vernonia amygdalina significantly (P<0.05) re-versed these changes in a concentration dependent manner.
Conclusion: In conclusion ethanolic leaf extract of Vernonia amygdalina have a potent hypoglycaemic and hepatoprotective action
against dimethylnitrosamine-induced liver damage in rats may be due to its antioxidant properties..
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 230.59 KB|
|Keywords:||Dimethylnitrosamine; Pre-treatment; Post-treatment; Vernonia amygdalina|
|Field of Study:||Biochemistry|
|Uploaded By:||Imarhiagbe Odoligie|
|Date Added:||22 Nov 2017 11:00am|
|Last Modified:||22 Nov 2017|
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