EFFECTS OF AQUEOUS AND ETHANOLIC EXTRACT OF VERNONIA AMYGDALINA LEAF ON THE PLASMA LIPID PROFILE AND LIVER FUNCTION PARAMETERS OF NORMAL RATS

Prof Usunobun Usunomena and C.O. Nwangwu Spencer, J. Josiah Sunday,, Nwangwu Udoka, A. Akinola Akintola, O. Isreal Ehiremen and Omage Kingsle   (Published 2011)

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Abstract

ABSTARCT

Many plants with reported medicinal value have been demonstrated to exert a protective effect on the liver and some, with the ability of lowering the blood lipid level have also been elucidated. This study shows the effect of ethanolic and aqueous extracts from  Vernonia amygdalina  on the plasma lipid profile as well as on the level of the liver biomarker in the plasma of normal rats. The animals were distributed into two sets of four groups with five animals in each group.  Each set had a control group while the other three groups were administered different concentrati ons of ethanolic and aqueous extracts from  V. amygdalina leaf. The control groups were administered normal saline and the other groups’ 100, 200 and 300 mg/kg of ethanolic and aqueous extracts respectively, twice daily for three weeks. The plasma Total Protein (TP), Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Aspartate Tran saminase (AST), Albumin (ALB) and Bilirubin (BIL) levels and plasma lipid profile of the rats were evalua ted. The aqueous extract of the plant showed a significant increase in the plasmaconcentration of HDL-C with no  significant difference in the plasma TC, LDL-C, VLDL-C and TG levels. Thus, these results suggested that the ethanolic extract from the leaves of  V. amygdalina had a hepatoprotective effect while hypolipidemic eff ect can be suggested for the aqueous extracts.


Item Type: Journal article(non-copyrighted)
Format: PDF document,   38.61 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: Biomarkers, hepatoprotective, hypolipidemic, Vernonia amygdalina
Department: Natural Science
Field of Study: Biochemistry
Uploaded By: Imarhiagbe Odoligie
Date Added: 22 Nov 2017 1:03pm
Last Modified: 28 Nov 2017
Journal URL: https://www.edouniversity.edu.ng/oer/journal/effects_of_aqueous_and_ethanolic_extract_of_vernonia_amygdalina_leaf_on_the_plasma_lipid_profile_and_liver_function_parameters_of_normal_rats


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