Abstract:
Purpose: The ethanolic root bark of Chrysophyllum albidum were evaluated for their effect on antioxidant
enzymes such as superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (malondialdehyde)
activities in rats.
Methods: Eighteen male Wister rats weighing 100-200g were divided into three groups of six animals each.
Two treated groups received a daily dose of ethanolic root bark of Chrysophyllum albidum at 100mg/kg and
200mg/kg body weight respectively via gastric gavage, while equal volume of normal saline was administered
to the control group for 3 weeks.
Result: All the in vitro models showed dose dependent activity. However the weight gain was dose related with
a decrease activity of SOD and CAT (p<0.05) in 100mg/kg treated rats, indicating an altered oxidative statues in
the animals but as the dose increase, SOD and CAT activity increase. MDA concentration was reduced (p<0.05)
in the treated rats.
Conclusion: The result suggests that the root bark extract of C. albidum has evidence of scavenging and
antiperodative properties.