EVI TIC E----------------------------- THE JANUS KINASE 2 (JAK2) MUTATION: A REVIEW OF ITS ROLE IN POLYCYTHAEMIA VERA AND OTHER MYELOPROLIFERATIVE DISORDERS
Dr Nwagu Marcellinus Uchechukwu (Published 2018)
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Background: Unlike Chronic Myeloid Leukemia (CML) whose genetic basis (the Philadelphia
chromosome), has become a household name, that of Polycythaemia Vera and other non-leukemic
myeloproliferative diseases has not equally received wide publicity.
Aim: The aim of this paper is to review and highlight the role of JAK2 mutation in Polycythaemia Vera,
Primary Myelofibrosis and Essential Thrombocythaemia.
Methods: Literature on the subject was reviewed using manual library search, articles in journals, internet
search and conference abstracts.
Results: JAK2 mutation plays important role in the general pathophysiology of non-leukemic
myeloproliferative diseases. Proper understanding of these roles is being utilized in research and
development of novel therapeutic agents.
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 5.49 MB|
|Department:||Medicine and Surgery|
|Field of Study:||Medicine|
|Uploaded By:||Uwaifo Ferdinand|
|Date Added:||15 Mar 2019 2:33pm|
|Last Modified:||15 Mar 2019|
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