KISSPEPTIN SYSTEM: A MULTI-HOMEOSTATIC SYSTEM

Dr Olaniyan Olugbemi Tope and Meraiyebu AB1, Auta K.B1, Dare J.B2, Anjorin Y.D3, Shafe M.O   (Published 2019)

Dr Olugbemi Tope
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Abstract

Abstract: The last decades have witnessed an upsurge of neuropeptides research. These substances regulate or
influence various functions in the body like appetite, water intake, learning and memory, adaptive responses to
environmental stress, thermoregulation and fever, social behaviour, and sleep. Kisspeptin (formerly known as
metastin) is a protein that is encoded by the KISS1 gene in the Anteroventral periventricular nucleus (AVPV)
and Arcuate nucleus (ARC) nuclei of the hypothalamus which was originally discovered in 1996 by Lee and
Welch while conducting oncology research at the Pennsylvania State University College of Medicine. It couple
to G-protein receptor ligand for (GPR54) G-protein receptor 54 (Messager et al, 2005). It is found to play many
important physiological roles which include: initiation of puberty, anti-oxidative effect, regulation of prolactin
release, glucose homeostasis, role in nutrition status and fertility, role in pregnancy, increases sensitivity of
chemoreceptors on type 2 carotid bodies, anti-metastatic effect, hot flushes in post-menopausal women.
Kisspeptins are so named because the arginine–phenylalanine residues are present at the amino terminal “Arg-
Phe-NH2”; all of the kisspeptin fragments have a C-terminal decapeptide that is critical for biological activity
(Clements et al, 2001; Kotani et al, 2001).


Item Type: Journal article(non-copyrighted)
Format: PDF document,   570.28 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: physiology
Department: Medicine and Surgery
Field of Study: Health and Society
Uploaded By: Uwaifo Ferdinand
Date Added: 06 Feb 2019 2:39pm
Last Modified: 06 Feb 2019
Journal URL: https://www.edouniversity.edu.ng/oer/journal/kisspeptin_system_a_multi-homeostatic_system


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