ABSTARCT

All procedures in the diagnostic medical laboratories are not without associated risks. Laboratory personnel handling clinical samples containing highly infectious agents are at a high risk of contracting laboratory-acquired infection. This risk is particularly high for those working in microbiological laboratories [1,2]. Injuries through infected needles and sharp cutting instruments encounteredin diagnostic procedures represent potential sources of laboratory-acquired infections.

ABSTARCT

Low birth weight (LBW) remains a global health challenge with both short and long term adverse consequences1. It is an important indicator of the health status of an infant and a principal factor that determines the infant survival, physical and mental development in the future2. Its etiology is complex and may vary from one setting to another. Delivery of LBW neonates has been associated with pre- term deliveries, anaemia, malnutrition and poor use of orthodox ante-natal services1,3,4.These are particularly…
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Background:

Ergonomics awareness helps in its right application and contributes significantly to general wellbeing and safety of worker at workplace. Aim: This cross?sectional descriptivestudy aimed at assessing the level of awareness and knowledge of the science of ergonomics mong Medical Laboratory Scientists in Benin City, Nigeria. Subjects and Methods: A totalof 106 medical laboratory scientists comprising 64 and 42 in public and private laboratories, respectively, were recruited for this study using systematic random sampling technique. Data were obtained…
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ABSTARCT

Sexually transmitted infections (STIs) including HIV/AIDS are global health concerns. Sexually transmitted infections are high among young people in Africa, largely due to high risk behaviour and neglect of potential preventive measures. Particularly distressing is the fact that nearly 3.3 million youth are living with HIV/AIDS in sub Saharan Africa, and 76% of these youth are women(1). In sub Saharan Africa young women within the age group of 15-24 years are 3-4 times more likely to be infected with…
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ABSTARCT

Hepatiatis B and C viral infections are global health problems.Data on the prevalence of these viruses among preganat women in rural Nigeria is missing. This study was carried out with a view to determine the prevalence of Hepatitis B and C Virus infections in pregnant women in Okada Community of Edo State,Nigeria and assess risk factors for their transmission. Venous blood was collected from two hundred and sixty seven (267) pregnant women with age ranging from 13-42 years. A…
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ABSTARCT

The human immunodeficiency virus (HIV) is a teething global health problem. Sub?Saharan Africa remains by far the most affected region, with 24.5 million people living with HIV, representing a little below two?thirds of all people living with HIV.[1] HIV epidemic affects females severely in the sub?region, and women of reproductive age make up 57% of adults living with HIV.[1] HIV infection in pregnancy is associated with adverse maternal and fetal outcome,[2] the effect of which includes among others infectious…
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ABSTRACT

Tuberculosis (TB) and HIV/AIDS are two worldwide public health concerns.[1] Co-infection of these two diseases has been considered to be a major obstacle for the global efforts in reaching the goals for the prevention of HIV and TB infections.[1] HIV infection is a risk factor predisposing to Mycobacterium tuberculosis infection and progression to active disease.[2] Findings from some studies indicate that peopleliving with HIV have a higher risk of developing multi-drug resistant tuberculosis (MDR-TB) which is associated with increased…
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Malaria is the world's leading parasitic disease and affects approximately 40% of the world's population (ap-proximately 2.4 billion people) in more than 100 countries (1). A life threatening illness arising from malaria infection, usually referred to as severe malaria, may occur in 1 – 2 % of infection (2, 3). Of the five clinically relevant Plasmodium species (Plasmodium falciparum, P. vivax, P. ovale, and P. malariae, P. knowlesi), P. falciparum mainly accounts for severe malaria, an important cause…
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ABSTARCT

Intestinal parasitic infections are associated with morbidity and mortality worldwide. Data on prevalence of intestinal parasitic infection is sparse in rural Nigeria. Against this background, this study aimed at determining the prevalence of intestinal parasitic infections within a four year period in the rural community of Okada, Edo State, Nigeria. Fecal samples obtained from 1528 patients (consisting of 740 males and 788 females) presenting with signs and symptoms of gastroenteritis at the Igbinedion University Teaching Hospital, Okada were examined…
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Abstract
Objectives: To determine the prevalence of malaria and anemia among pregnant women attending a traditional birth center as well as the effect of herbal remedies, gravidity, age, educational background and malaria prevention methods on their prevalence. Methods: Blood specimens were collected from 119 pregnant women attending a Traditional Birth Home in Benin City, Nigeria. Malaria parasitemia was diagnosed by microscopy while anemia was defined as hemoglobin concentration Results: The prevalence of malaria infection was (OR=4.35 95% CI=1.213, 15.600; p=0.016) higher among primigravidae (92.1%). Pregnant women (38.5%)…
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Abstract
Aim: To determine the prevalence of urinary tract infection (UTI) in Okada, a rural community in Nigeria, and the effect
of age and gender on its prevalence as well as the etiologic agents and the susceptibility profile of the bacterial agents. Patients and Method: Clean-catch midstream urine was collected from 514 patients (49 males and 465 females). The urine samples were processed and microbial isolates identified. Susceptibility testing was performed on all bacterial isolates. Result: The prevalence of urinary tract…
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METHODS: Clean-catch urine was collected from 220 pregnant women attending a traditional birth home in Benin City, Nigeria. Urine samples were processed, and microbial isolates identified using standard bacteriological procedures. A cross-sectional study design was used.

CONCLUSIONS: The prevalence of urinary tract infection among pregnant women was 55.0% and significantly affected by gestational age and parity. The most prevalent etiologic agent observed was Escherichia coli. With the exception of the flouroquinolones, aminoglycoside, and Amoxicillin-cluvanate, the activity…
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Abstract
Background: Wound infections are associated with increased morbidity and mortality. Objectives: To determine the prevalence, aetiology and susceptibility profile of bacterial agents of wound infection among in- and- out patients at a rural tertiary hospital in Nigeria, within a 5 year period. Methods: Wound swabs collected from 156 out-patients and 353 in-patients were, cultured and microbial isolates identified using standard methods. Antibiotic susceptibility testing was done on bacterial isolates. Results: The prevalence of wound infection in 2006, 2007, 2008, 2009 and 2010 was 71.4%,…
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ABSTRACT
Molecular typing techniques have been employed in the epidemiological study of methicillin-resistant S. aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci (MRCoNS) to identify the staphylococcal cassette chromosome mec (SCCmec) elements. The aim of this study was to determine the prevalence and diversity of SCCmec types in the isolates obtained from four hospitals in south-south, Nigeria. A total of 149 staphylococcal isolates were obtained from clinical samples from March through September, 2015. They were identified and SCCmec typing was done using single-target PCR. The prevalence of methicillin-resistant staphylococci…
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Sub- Saharan Africa remains by far the most affected region with about 24.5 million people living with HIV, representing a little below two-thirds of all people living with HIV in the world(Oladeinde et al., 2011 )

HIV infection is a major health concern in Nigeria, where it is estimated that about 2.9 million people are living with the virus (Monjok et al., 2009 ).

Study Background: Moringa oleifera, (miracle tree), has been used in the treatment of numerous diseases. Moringa has been
the subject of intensive scientific research; however, there have been scanty information
on its sub-acute effect on the kidneys.
Aims: This work was done to investigate the histological and biochemical effect of M. oleifera on the heart
and kidneys of adult Wistar rats.
Settings and Design: Twenty-eight adult healthy rats were used for this study. The rats were divided into
4 groups…
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Abstract
is a proinflammatory cytokine which acts to worsen disease while IL-10 is an anti-inflammatory
cytokine, which acts to improve healing. Plasmodium falciparum co-infection with Mycobacterium tuberculosis
could generate both innate and acquired immunity involving inflammatory responses. This work was
designed to determine plasma level of TNF-Alpha and IL-10 in plasmodium co-infection with
Mycobacterium tuberculosis. The test subjects recruited for this study were M. tuberculosis mono-infected
patients (30), Plasmodium falciparum mono-infected patients (50) and M. tuberculosis and plasmodium coinfected
patients…
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ABSTRACT
Lassa fever caused by lassa virus is anhaemorragic infectious disease with limited access to
diagnostic facilities in Nigeria. Lassa virus infections can only be diagnosed definitively in the
laboratory using the following tests: reverse transcriptase polymerase chain reaction (RT-PCR) assaygold
standard, antibody enzyme-linked immunosorbent assay (ELISA), antigen detection tests and
virus isolation by cell culture. Cases of this infectious disease have been reported in 24 of the 36
States in Nigeria. Currently, two national laboratories are supporting the laboratory…
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Background:
Objectives
Method:
Results:
Conclusion:
Synergistic association between Human Immunodeficiency virus (HIV) and
pulmonary tuberculosis (PTB) infection has resulted in variable haematological manifestations
including coagulopathies; these accelerated the morbidity and mortality burden of HIV/PTB coinfection.
: Based on this preposition, we prospectively evaluated some coagulation biomarkers
in a case-controlled study of 102 HIV sero-positive subjects consistent withWHOclinical stages I
and II, 56 HIV/PTB co-infected subjects; both groups were therapy naive. Also 104 HIV seronegative
healthy blood donorswere recruited as control…
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Abstract: Hepatitis B and C viruses cause viral hepatitis which could affect the function of the liver. Viral hepatitis is
one of the major killer diseases associated with malaise but could be prevented. This work was designed to investigate
the frequency of HBsAg, and anti-HCV including their effects on some biochemical parameters among University
Students presenting with malaise. Fifty malaise University students were recruited through their Health Centre. The
students were screened for anti-HCV, anti-HIV and HBsAg Immunochemical by ELIZA…
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Abstract Anthropometric indices and lipid profiles are useful markers of malnutrition and could reveal risk of cardiovascular disease. This work aimed at evaluating the anthropometric indices and lipid profiles in students of tertiary institutions. Anthropometric indices and lipid profiles were evaluated in 200 students of students of tertiary institutions including Achievers University and Rufus Giwa Polytechnic, Owo, Nigeria, aged 18 -46 years, comprising 95 males and 105 females recruited for this study. Anthropometric measurements including weight, height, and waist and…
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Abstract Background: Anthropometric indices, plasma albumin, uric acid and packed Cell Volume(PCV) are good markers of malnutrition and the associated disorders. Aim and Objective: This work aimed to evaluate the anthropometric indices, plasma albumin, uric acid and packed cell volume in tertiary institution students. Materials and Methods : Anthropometric indices, plasma albumin, uric acid and packed cell volume (PCV) were evaluated in 200 students of two tertiary institutions in Owo-Nigeria which include Achievers University and Rufus Giwa polytechnic, Owo, Ondo…
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ABSTRACT
Background: Solanecio biafrae (Wòròwó) contains phytochemicals, specifically antioxidants such as vitamins with effective health benefits as it is evidenced in the use of the vegetable in traditional treatments. Acetaminophen is an anagelsic which people used irrationally that could lead to drug abuse and inflammation of the liver in overdoses or prolong administration, notwithstanding the normal therapeutic dose is safe. Materials and Methods: Fifteen rabbits of the same sex (male) with weight ranging from 1.0 -1.4 Kg were classified into…
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ABSTRACT
Background: Watermelon juice has many non- scientific health beneficial claims due to its bioactive chemical constituents. Acetaminophen Extra contains paracetamol (500mg) and caffeine(65mg) used to relieve pain. Aim and Objective: This work was designed to evaluate the effect of watermelon juice in rabbits overdosed with acetaminophen extra using plasma zinc, potassium, chloride and sodium. Materials and Method: Thirty rabbits classified into six experimental groups labeled A-F (with C1, C2, E1 and E2) with A as control were investigated. An…
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Abstract: Water melon juice contain potent antioxidants such as lycopene in addition to other health promoting bioactive
phytochemicals. Overdoses of the analgesic and antipyretic acetaminophen extra represent one of the most common
pharmaceutical product poisonings worldwide today. This work was designed to evaluate the effect of watermelon juice
in rabbits overdosed with acetaminophen extra using Total cholesterol, Triglyceride, HDL and LDL. Thirty rabbits
classified into 6 groups labeled A-F (with C1, C2, E1 and E2) with A as control were…
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Abstract: Obesity is the result of interplay between genetic and environmental factors. Polymorphisms in various genes
controlling appetite and metabolism predispose to obesity when sufficient calories are present. It is not known whether
polymorphisms in FXR gene are associated with high lipid level among obese individuals. This study was designed to
investigate and compare the lipid profile and polymorphism of the FXR gene in obese individuals, overweight and
normal weight individuals. We investigated 35 obese subjects, 35 overweight subjects and…
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Abstract
Thirty anaemic pregnant women aged 29.5± 6.5 years with baseline mean packed cell volume (PCV) of 20.8 ± 2.0% were studied. Freshly prepared Ugu (pumpkin-Telfaira occidentalis) mixture containing ugu (pumpkin) fluid, raw content of egg and peak evaporated unsweetened milk was administered orally to each of the pregnant women three times in a day for seven days. Packed cell volume was carried out by capillary tube method. There was an observed significantly mean value of PCV (29.5 ± 2.2%…
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Abstract
Human immunodeficiency Virus/ Acquired immunodeficiency syndrome (HIV/AIDS) seronegative pulmonary
tuberculosis (PTB) patients (n=30; 15 females and 15 males) Aged 20 – 61 years; HIV/AIDS seropositve.
Mycobacterium tuberculosis free subject (n= 30: 18 females and 13 males) aged 17 – 42 years and 50 HIV/AIDS
seronegative mycobacterium tuberculosis free subjects (25 females and 25 males) aged 2 – 70 years were used as the
tests and the normal control. HIV/AIDS screening/ tests were carried out on all the subject groups.…
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THE PATTERN OF PACKED CELL VOLUME, PLASMA ELECTROLYTES AND GLUCOSE LEVELS IN PATIENTS INFECTED WITH PLASMODIUM FALCIPARIUM

Abstract
Fifty HIV disease/AIDS seronegative subjects aged 23.6 ± 16.5years (female=25: male =25) were
recruited as normal control subjects. Thirty HIV disease/AIDS seropositive patients that presented with
the symptoms of AIDS especially, aged 19.2 ± 10.7years (female: 15 aged 22.0 ± 12.1 years: males = 15
aged 20.6 ± 11.3years) were used as test subjects. Serum total calcium, magnesium and zinc were
analysed using atomic absorption spectrophotometry and HIV tests were carried out on each of the
subjects. There was…
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Abstract
Thirty Human Immunodeficiency Syndrome (111V infection/AIDS)
Seropositive patients aged 27.53 ± 15.4years (Female -16: male -14) Iliat presented with the clinical signs and symptoms of the disease and fifty HIV /AIDS seronegative subjects aged 27.62 ± 21.4years (female-25: Male-25) were recruited into the study as test and normal control subjects respectively. Human immunodeficiency virus tests were carried out on each of the subjects in the two subject groups. Analysis of total serum cholesterol, iron (Fe], and albumin were carried…
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Abstract
Blood group status appears to be associated with susceptibility to infections. Sixty two Human Immunodeficiency virus (HIV) Seropositive patients (32 females and 30 males) aged 1-61 years and two hundred (120 females and 80 males) aged l-70years were recruited into the study as test and control participants. HIV screening and confirmatory tests were carried out on each of the participants. The AB.O and Rhesus blood grouping was carried out by standard tube and tile technique.The patterns of the frequency…
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ABSTRACT
Sixty HbSS sickle cell anaemic patients aged 17.45 ±10.1years (Female=30, Male=30) and sixty HbSC sickle cell disease patients aged 20.6±11.0years(Female=30,Male=30) were recruited for the investigation. Haemoglobin genotype of each of the patient was determined by electrophoresis. HepatitisB‘s’ antigen, HBeAg,anti-HBe, and anti-HCV in patients’ plasma were determined by Enzyme Immunoassay.
The frequencies of HBsAg, anti-HBe, HBeAg +HBsAg, HBsAg + antiHBe, in HbSS(6.7% , 20%,13.3%, and 20% respectively) were higher than those of HbSC( 5% ,8.3%, 5% , and 3.3% respectively).…
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ABSTRACT
;/ descript ive cross -, section analysis 0/ five hundred patients who were
symptomatically diagnosed of malaria in three locations: Saki (peri-urban), Ibadan
(urban) and Lagos (highly urbanized) were recruited /01' this study using a well
structured questionnaire between September 2005 and June 2006. The prevalence
0/ both malaria and HIV infections were higher in Peri-Urban town than the other
two locations. We observed that 80% were HIV positive in Saki. 20% in Ibadan
and 37. J % in…
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Abstract
Serological ABO and Rhesus blood groupings could be used to predict the possible ABO and Rhesus blood group genotype. In this study, ABO and Rhesus blood group genotypes of given six subjects were predicted and employed to establish possible family ties between them. Based on their ABO and Rhesus phenotype, five of the family members indicated a possible family lineage. The last child showed an ABO blood group that might not be a product from the apparent parents. As…
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Abstract
Individuals donate blood for altruistic reasons or to
their patients which are either their relatives or
friends. Donation may be whole or part of blood by
apheresis donation. The knowledge of the benefit or
side effects of blood donation is paramount to blood
donors. The aim of this study was to evaluate the
possible benefit or side effects on blood donors
through haemorheological indices. Blood sample of
116 apparently healthy, non-smoking, non-alcoholic,
HIV 1 and 2, HCV, HBsAg and…
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ABSTRACT
lterations in fibrinogen levels of patients with chronic liver disease (CLD) in Maiduguri was Astudied. However, the dimension of this observation in Maiduguri has not been formerly
established. Fifty clinically diagnosed and laboratory confirmed CLD patients attending
the UMTH had their plasma fibrinogen concentration (PFC) estimated by automation. Apparently,
fifty healthy individuals who are HIV, HBsAg and HCV negative were included as a control and
undergo the same test. Among the CLD patients, 20-29 years' age group have a…
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ABSTRACT

Background: Hepatotropic virus infection, such as Hepatitis C Virus (HCV) infection is altering
the gains of highly active Antiretroviral therapy HAART; and rapidly increasing non-AIDSrelated
mortality in people living with HIV disease.
Aim: This warranted the investigation of some biochemical indices in a Cohort of 94 HIV
Seropositive Subjects, out of which 11 were co-infected with HCV. Controls consisted of 80
subjects Seronegative for HIV and HCV antibodies.
Method: We analysed Aspartate Transaminase (AST), Alanine transaminase (ALT), Alkaline READ MORE Download Staff Profile      

Summary
The current standard blood processing practice is to split blood into its various components usually done by a process such as aphaeresis or whole blood donation involving centrifugation and filtration. This paper review the elements that should be considered when choosing a method and which components to produce based on the risks and benefits to the blood system operation, the donor and the recipient. Specific haemotherapy is safer than the use of whole blood. Overall, considering efficacy and economy,…
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ABSTRACT

Background: The emergence of inexplicable thrombotic events with unrecognised mechanism
in the recent times warranted the investigation of otherwise-uncommon risk factors for
thromboembolic phenomena. It is a common cause of inherited thrombophilia associated with
venous thromboembolism (VTE), recurrent pregnancy loss, infertility, contraceptive or
hormone replacement related coagulopathy, and cerebral palsy. This study therefore aimed at
exploring the of factor V –Leiden (FVL) gene mutation among the natural population
of Maiduguri.
Methods: This is a cross-sectional study which was…
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ABSTRACT

Background: The emergence of inexplicable thrombotic events with unrecognised mechanism
in the recent times warranted the investigation of otherwise-uncommon risk factors for
thromboembolic phenomena. It is a common cause of inherited thrombophilia associated with
venous thromboembolism (VTE), recurrent pregnancy loss, infertility, contraceptive or
hormone replacement related coagulopathy, and cerebral palsy. This study therefore aimed at
exploring the of factor V –Leiden (FVL) gene mutation among the natural population
of Maiduguri.
Methods: This is a cross-sectional study which was…
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VITAMINS AND MICRONUTRIENTS LEVEL AMONG TRANSFUSION-DEPENDENT SUBJECTS IN MAIDUGURI, NIGERIA.

ABSTRACT
Conditions with refractory anaemia require continuous blood transfusion as the
cornerstone of treatment to lessen symptoms and improve quality of life. However, longterm
red blood cell transfusion therapy results in accumulation of iron in tissues. Serum
ferritin is significantly correlated with the body iron store, therefore, periodic evaluation
of ferritin in a transfusion-dependent patient is necessary. Hyperferritinaemia predicts
end-organ involvement causing morbidity and mortality. These consequences could be
prevented by iron chelation therapy.
Aim: The aim of this study…
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Abstract
This study investigates the efficacy of ginger (Zingiber officinale), garlic (Allium sativum) and both plants combined in rats
infected with Kleibsiella pneumoniae. The rats were treated with the plant extracts after symptoms of pneumonia infection were
noticed in all the groups; the treatment lasted for seven consecutive days. The average weight gains in the post-administration
were: in garlic, ginger, mixture (males), mixture (females) and control were 27.0g,-36.2g, 6.0g, 38.8g and 78.8g respectively.
There was a significant reduction in packed…
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Abstract

This study investigates the efficacy of ginger (Zingiber officinale), garlic (Allium sativum) and both plants combined in rats
infected with Kleibsiella pneumoniae. The rats were treated with the plant extracts after symptoms of pneumonia infection were
noticed in all the groups; the treatment lasted for seven consecutive days. The average weight gains in the post-administration
were: in garlic, ginger, mixture (males), mixture (females) and control were 27.0g,-36.2g, 6.0g, 38.8g and 78.8g respectively.
There was a significant reduction in packed…
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Abstract
Jaundice is associated with hepatitis B virus infection due to the destruction of the infected hepatocytes and intrahepatic-cholestasis caused by the scars of the healed hepatocytes. Hepatitis B patients that have never had jaundice are referred to as preicteric patients, while those that have recovered from jaundice are referred to as posticteric hepatitis patients. Those ones suffering from jaundice are referred to as icteric patients. This research work was designed to determine and compare the serological profiles of HBsAg…
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Abstract
Jaundice is the yellowish pigmentation of sclera of eye, skin and body fluids. It is associated with hepatitis B
virus infection due to the destruction of the infected hepatocytes and intrahepatic-cholestasis caused by the scars
of the healed hepatocytes. Hepatitis B patients that have never had jaundice are referred to as preicteric patients,
while those that have recovered from jaundice are referred to as posticteric hepatitis patients. Those ones
suffering from jaundice are referred to as icteric patients. This…
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Abstract
This work was designed to characterize the HIV viral antibodies in HIV infected and non-HIV infected HBsAg
seropositive patients. Fifty non HIV infected (male = 25; female = 25)and 50 HIV infected HBsAg seropositive
patients (male – n = 25; female – n = 25) aged 6 – 64 years recruited from the medical outpatient department of
Baptist Medical Centre, Saki – Oyo State – Nigeria were investigated as test subjects. Fifty apparently healthy
HIV and HBsAg seronegative individuals…
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Abstract
Worsened perinatal outcomes and increased rates of maternal morbidity are consequences of co-infection of HIV and
Plasmodium falciparum in pregnant women. This study was designed to ascertain the proportion of co-infection of
both diseases in pregnant mothers and babies born to HIV-infected mothers.
A total of 149 pregnant mothers and 30 babies of HIV-infected mothers were engaged in a longitudinal study for 18
months in the endemic area of Saki and Ibadan. Only babies born to HIV infected mothers…
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Abstract
Heamolytic disease of the newborn is a neonatal disease associated with red cells heamolysis resulting
from red cell antigens of the foetus and mother red cells antibodies. This study involved a
cross sectional laboratory based analytical survey, eighty neonates with pyrexia of unknown origin
and twenty neonates apparently healthy were selectected for this study. ABO and Rh blood
group, Direct Coombs’ test, Glucose-6-phosphate dehydrogenase estimation and blood culture
were performed on blood samples collected from each neonate. Blood group…
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Abstract Raw liquid extract of Avocado pear leaf is of medicinal importance in the treatment of hypertension. In Oke-Ogun area of Oyo state, this extract is being used as an alternative therapy in the treatment of hypertension in human subjects. This work was designed to evaluate the Effect of Liquid Extract of Pear Avocado Leaf used in the Traditional Treatment of Hypertension on the Plasma Levels of Aminotransferases, Total Bile Acids, Total and Low Density Lipoprotein Cholesterol. Fifty (50) anicteric…
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Abstract Patients confirmed to be seropositive for human immunodeficiency Virus (HIV) infection by Western blot technique attending Baptist Medical Centre, Saki, Oyo state-Nigeria were studied; including 30 males; 30 females; 20HIV mono-infected, 20HIV-HBV co-infected, 20HIV-HCV co-infected subjects aged 16 to 65 years. Age and sex matched apparently healthy HIV, HCV and HBV seronegative, subjects (N=50) consisting of 25 (50%) males and 25 (50%) females were recruited as controls. Plasma ALT, AST and Total Bile Acids were determined in the subjects…
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Abstract Background to the study: Pathophysiology of Plasmodium (vivax, ovale, falciparum and malariae) infection involves liver. Liver dysfunction and destruction of tissues could be indicated by the plasma level of Total Bile Acid (TBA) and Lactate Dehydrogenase (LDH). Aim and Objective: This work was designed to evaluate the pattern of parasite density, plasma total bile acids, and Lactate dehydrogenase in Plasmodium infected patients in rural community. Materials and Methods: The study was carried out in Kishi, the Headquarter of Irepo…
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Abstract Background to the Study: Pathophysiology of Plasmodium infection and the metabolism of the phytochemicals of raw liquid extract of Vernonia amygdalina used in the traditional treatment of Plasmodium spp infection in Saki-East Local Government area of Oyo state -Nigeria involve the hepatocytes, which could bring about biochemical alterations in the plasma level of albumin, fibrinogen, Lactate dehydrogenase (LDH) and Total Bile Acids (TBA). Aim and Objective: This work was designed to determine the effect of the raw extract of…
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Abstract Background to the Study: Blind therapeutic management is a common feature of the traditional management of clinical cases that may obscure immunochemical and biochemical abnormalities such as viral infections and abnormally raised total bile acid (TBA) which may make treatments unsuccessful. Aim and Objective: This work was designed to determine some viral markers of patients with abnormally raised Total Bile Acid receiving treatments in herbal/traditional homes of some rural communities in Nigeria. Materials and Method: Fifty one (51(25.1%)) of…
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Abstract This study was carried out to determined the variation in microbiota of five section of Igbinedion University Teaching Hospital Okada. Samples were collected using the settled plate techniques for the enumeration of bacterial and fungal isolates. The air specimens were collected three times; in the morning between the hours of 8 am and 10 am, in the afternoon between 12 noon and 2 pm and in the evening between the hours of 4pm and 6pm. The total heterotrophic microbial…
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Abstract Corn silk contains phytochemicals of medical benefits such as proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Extract of corn silk is being applied traditionally in the treatment of some medical conditions. This study therefore, aimed at the evaluation of the effect of corn silk extract on liver markers and plasma glucose. Fifteen rabbits of either sex divided into three experimental groups of…
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ABSTRACT The risk of diabetic nephropathy in type 2 diabetes is about 30-40%, and it is considered the leading cause of end-stage renal disease. This Study is aimed to determine the association between non-HDL cholesterol and inflammation in the development of diabetic nephropathy and to identify a possible predictor for diabetic nephropathy in type 2 diabetic patients. Eighty diabetic subjects were recruited for the study; 40 diabetic and normoalbuminuric were used as positive controls and another 40 diabetic and microalbuminuric…
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Abstract
Liver markers indicate liver disorders that could be caused by drugs and infection such as hepatotropic viruses or
its co-infection with HIV. Standard antiretroviral therapy (ART) consists of the combination of at least three
antiretroviral (ARV) drugs to maximally suppress the HIV virus and stop the progression of HIV disease. This
study was designed to determine the effect of antiretroviral therapy in co-infection of HIV with hepatitis B virus
on serum ALT, GGT and LDH. Seventy six patients aged…
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Abstract
This study was designed to determine the serum albumin, GGT and LDH level in relationship with the CD4
count and hepatitis B and C coinfection in HIV patient. Sixty HIV patients aged 16 to 75 years classified
according to the CD4 cell count value and with reference to HBV/HCV co-infection status were studied. Viral
Immunochemical status of the patients was determined by ELIZA and Immunoblotting. CD4 cell count was
estimated by flow cytometry while the plasma LDH, GGT and…
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Abstract
Background to the Study: Corn silk contains phytochemicals of medical benefits such as proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and flavonoids. Aim and Objective: This study aimed at the evaluation of the scavenging property of corn silk extract in oxidative stress induced rabbits using corticosterone. Materials and Methods: Fifteen rabbits divided into three experimental groups (A-Control, B-treated with aqueous extract and C-treated with…
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Abstract:
Watermelon juice is commonly used as beverage and to relieve thirst. It contains phytochemicals like alkaloids, flavonoids, saponnins. The fruits are rich in lycopene and with a total antioxidant capacity similar to tomato The fruits are also rich source of ? -carotene, vitamins (B, C and E), minerals (K, Mg, Ca and Fe), amino acid (citrulline) and phenolics. This work therefore aimed at determining yhe health promoting bioactivities of fruit juice of water melon (citrullus lanatus) in rabbits overdosaged…
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Abstract:
Physiological and hormonal changes in ovulation could increase the severity of asthma as a result of increase in cellular immune response leading to excessive release and utilization of immune cells in response to the allergic reaction. This work aimed at determining possible alterations in haematological parameters in asthmatic female students during ovulation. Thirty (30) asthmatic female students aged 17 to 41 years observing regular menstrual cycle as test subjects and fifty (50) non asthmatic female students aged 18 to…
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Abstract
Background: Liquid extract of Morinda lucida leaf has been demonstrated to have antiplasmodial activities. Some phytochemicals
act as preventive and or scavenging antioxidants. This study aimed to investigate the preventative and scavenging properties of
the raw liquid extract of M. lucida leaf using plasma myoglobin, transferrin, superoxide dismutase (SOD), and glutathione (GSH)
peroxidase. Materials and Methods: Forty-eight Plasmodium-infected patients aged 29-47 years that have not been treated with
any antimalaria medication but have decided to be treated traditionally using…
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Abstract
Background: HbSS and HbSC are a group of genetic blood disorders. They are examples of sickle cell diseases.The complication of sickle cell disease could affect spleen, brain, eyes, lungs, liver, heart, kidneys, penis, joints, bones, or skin. Aim and Objective: This work was designed to measure plasma ALT, AST, Albumin,Se, Zn and Uric acid in HbSS and HbSC patients in Saki-West Local Government area of Oyo state-Nigeria. Materials and Methods: HbSS and HbSC patients in crisis and in non-crisis…
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ABSTRACT
Background
Basella alba (amunututu) is a common leafy vegetable commonly prepared as soup among the Yoruba ethnic groups. It contains phytochemicals such as tannin, saponin, alkaloid, terpenoid, flavonoid, glycoside, phenolic, vitamins and minerals.
Aim and Objective
This study was designed to determine the lowering effect of ethanolic and aqueous extract Basella alba on Total cholesterol(CHOL-T), Low Density Lipoprotein-cholesterol(LDL-C),Total Triglycerides(TG-T), High Density Lipoprotein-cholesterol (HDL-C).
Materials and Methods
Twenty five rabbits weighing 0.7-1.3Kg classified into five experimental groups of 5 rabbits…
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ABSTRACT
Background
While co-infection with HBV and malaria is a major public health problem in large areas of the world, the mutual interactions between the two pathogens are poorly understood.
Aim and Objective
This study is designed to investigate the renal biomarkers in plasmodium infected HBsAg seropositive patients. Method
Semi structured and pre tested questionnaires were administered to 100 participants to obtain their demographic information. From each individual subject, 5 ml of blood sample was obtained via venopuncture from the…
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ABSTRACT
Background
Worldwide, breast cancer is the most common cancer in women, being one of the leading causes of death among women and men. Emerging evidence suggests the role of lipid in the development of breast cancer. It becomes a great concern for the modern man and medical curiosity to further investigate alteration in lipid profile and hormone sensitive lipases genes among breast cancer patients in Nigeria.
Aim and Objective
This study was designed to investigate and compare the atherogenic…
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Abstract

Background:- Jaundice is a common clinical condition among anaemic children.
Aim and Objective:- This work was designed to evaluate the Plasma Level of Total Antioxidants and Frequency of HbSC, HbSS, HbAA, HbAS, HbAC and G6PD Deficiency in Icteric Children Presenting with Anaemia.
Materials and Methods:- One hundred icteric children aged 3-12 years presenting with anaemia were recruited for this work from the General Hospital, Oka-Akoko-Ondo state.Alkaline cellulose acetate membrane haemoglobin electrophoresis was carried out on the subjects to…
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Abstract: Herbal treatment is currently attracting more patronage due to the effectiveness and low cost of treatments.
Many herbs contains phytochemicals of health benefits. Some traditional ways of administering herbal treatments could
bring about cross-infection. This work was designed to determine the biochemical and Immunochemical status of
patients receiving herbal treatment in some herbal homes in rural Nigeria. Fifty patients receiving herbal treatments
were recruited for this work. The patients were tested for anti-HIV, anti-HCV and HBsAg immunochemically by ELIZA READ MORE Download Staff Profile      

Abstract: Cashew leaves (Anacardium occidentale) is a medicinal plant applied in the treatment of some nonscientific
claims of common diseases in South-Western Nigeria such as hypertension . It contains phytochemicals such
as Phenolic, flavonoids, steroids, triterpenes and 33.52% to 46.26% of dietary fiber. This work was therefore designed
to determine the Cholesterol Lowering Effect of Cashew leaf (Anacardium occidentale) extract on Egg Yolk Induced
Hypercholesterolaemic Rabbits. Fifteen rabbits classified into control group A of five rabbits; experimental group B
induced…
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Abstract:
Background: Watermelon juice that contains antioxidants in addition to other vitamins and minerals is being used as beverage to alleviate thirst in Nigeria. Acetaminophen extra is most available to people and could be irrationally used to relieve pain. Aim and
Objective: This work was designed to evaluate the effect of watermelon juice in rabbits overdosed with acetaminophen extra using Creatinine, Urea, Glutathione-S-transferase, and Uric acid.
Materials and Methods: Thirty rabbits classified into six experimental groups labelled A-F (and sub…
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Abstract
Background: Corn silk contains health promoting phytochemicals which could be applied in the treatment of cardiovascular diseases. Aim and objectives: This was designed to evaluate the effect of corn silk extract on lipid profile, CK-MB and LDH. Methods: Fifteen rabbits divided into three experimental groups of 5 rabbits each were studied. The control group(A) was not ingested with the extract throughout the period of study. Group B was ingested with the water extract for 3 weeks while group C…
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ABSTRACT
Background: Watermelon juice contain antioxidants in addition to other vitamins and minerals consumed as
beverage to relieve thirst in Nigeria as it is made up of 90% water. Panadol extra is most available analgesic to
many people and could be irrationally used to relieve pain.
Aim and Objective: This work was designed to evaluate the effect of watermelon juice in rabbits overdosed
with Panadol extra using Lactate Dehydrogenase (LDH), C - reactive protein (CRP) and Haptoglobin (Hp).
Materials and…
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ABSTRACT
Background to the Study: Malabar Spinach (Amunututu in Yoruba) - Basella alba, is a common leafy
vegetable that contains phytochemicals such as tannin, saponin, alkaloid, terpenoid, flavonoid, glycoside and
phenolic compounds in addition to vitamins and minerals.
Aim and Objective: This study was designed to determine the hepatoprotective effect of ethanolic and aqueous
extract Malabar Spinach in rabbits overdosed with paracetamol.
Materials and Methods: Thirty rabbits weighing 0.7-1.4 Kg classified into five experimental groups of 5
rabbits each labeled…
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ABSTRACT
Background: Watermelon juice is a common bevrages used as food supplement for refreshment in most cases
to relief thirst. It contains health promoting phytochemicals, vitamins and minerals. Panadol extra is a common
drug used to relief pains. These two materials are easily accessible to people and as such could be abused.
Aim and Objective: This work was designed to measure the effects of watermelon on Total Antioxidant Status,
Red Blood Cell (RBC), Packed Cell Volume (PCV), Haemoglobin (HB), Mean…
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ABSTRACT
Background: Solanecio biafrae (Èfó Wòròwó) is an important vegetable plant commonly grown in cocoa
plantation in South-West geopolitical zone of Nigeria majorly in Ondo and Ekiti-States which has some
traditional treatment claims such as cough-cure, for heart-troubles, to stop bleeding from cuts, rheumatic pain,
prurigenic, allergies and localized oedemas.
Aim and Objective: This study was designed to determine Scavenging antioxidative bioactivities of Solanecio
biafrae (Wòròwó).
Materials and Methods: Twenty five rabbits classified into 5 groups of five rabbits each…
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ABSTRACT
Background: Raw extract of Guava leaves (Psidium guajava) have been used effectively and traditionally to
treat common ailments such as Diabetes mellitus (type II) diarrhoea, toothache and hypertension in South
Western Nigeria. These are non-scientific health benefit claims.
Aim and Objective: This study was designed to determine cholesterol lowering effect of guava leaf (Psidium
guajava) extract on egg yolk induced hypercholesterolemic rabbits.
Materials and Methods: Fifteen rabbits were bought from OjaIkoko-a major market in Owo-Nigeria.
This rabbits were grouped…
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ABSTRACT
Background: Watermelon juice that contains antioxidants in addition to other vitamins and minerals is being
used as beverage to alleviate thirst in Nigeria. Quantitative phytochemical analysis of watermelon juice revealed
4537.83?g/100g Lycopene and 308.71 ?g/100g ?-carotene as major and potent antioxidants. Panadol extra
contains 500 mg Paracetamol and 65 mg Caffeine. It is available to people over the counter and is being used
blindly to treat pain. Glutathione and cysteine have antioxidant properties. Glutathione biosynthesis requires
amino acids such…
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ABSTRACT
Background: Watermelon juice contains phytochemicals like alkaloids, flavonoids, saponnins, 68.0285 mg/k
fresh wt of lycopene (a major and potent antioxidant found in the succulent part of the fruit), including ? -
carotene, vitamins (B, C and E), minerals (K, Mg, Ca and Fe), amino acid (citrulline) and phenolics. Panadol
extra contains 500 mg of acetaminophen and 65 mg of caffeine. Panadol Extra is 30% more powerful when
compared to standard paracetamol.
Aim and Objective: This work was designed to…
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Abstract
Severe clinical manifestations of asthma have been associated with menstrual cycle. Possible complication of asthma was reported to be infertility. White yam commonly used as food in South- West in Nigeria contains antioxidants and phytoestrogen. Aim and Objective: This work was designed to determine the bioactivities of two weeks white yam (Dioscorea rotundata) diet in asthmatic female students in relationship with mentrual cycle using luteinizing hormone, follicle-stimulating hormone, glutathione peroxidase and superoxide dismutase. Thirty nine asthmatic female students of…
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ABSTRACT
Study Background: Guava (Psidium guajava) fruit juice contains health promoting bioactive phytonutrients
and phytochemicals applied in the traditional treatment of diseases in southwestern Nigeria. It is an edible fruit
taken by almost everyone as beverage. Acetaminophen extra contains 500mg of Acetaminophen and 65mg
Caffeine and as such the drug is commonly used to relieve pain. The drug is readily accessible by individuals
making it susceptible to drug abuse especially overdose.
Aim and Objective: This work was therefore designed to…
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A B S T R A C T
________
1. INTRODUCTION
Complement C3 and C4 are innate immune materials but
could interplay between adaptive and innate immunity 1.
Their major functions include: opsonization, lysis and
International Journal of Pharma Research and Health Sciences
Available online at www.pharmahealthsciences.net
Received: 21 Mar 2017
Accepted: 05 April 2017
Haptoglobin (Hp) is an acute phase protein and also an immune parameter produced by the
liver which binds free haemoglobin in the blood. Complement 3…
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A B S T R A C T
________
1. INTRODUCTION
Increase in the incidence and prevalence of human
immunodeficiency virus (HIV) infection has been linked
with women of child-bearing age internationally. Vertical
International Journal of Pharma Research and Health Sciences
Available online at www.pharmahealthsciences.net
Received: 13 Mar 2017
Accepted: 26 Mar 2017
Study Background: Unplanned Teenage pregnancy out of wedlock could be as a result or
cause psychosocial and economic challenges which may make the affected teenager
susceptible to…
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ABSTRACT
Study Background: Cnidoscolous aconitifolius leaf (Chaya; Efo Iyana ipaja in Yoruba language)
is a common vegetable plant served as sauce and has many traditional health benefit claims such
as treatment of alcoholism, insomnia, gout, scorpion stings, memory and vision impairment owing
to its phytochemical and phytonutrient constituents.
Aim and Objectives: This work was designed to determine the cholesterol lowering effect of
Cnidoscolous aconitifolius in rabbits induced with hypercholesterolemia using egg yolk.
Materials and Methods: Fifteen (15) rabbits grouped into…
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ABSTRACT
Study Background: Flunitrazepam, Tramadol and Codeine are irrationally used as energy
booster, psychoactives and as recreational drugs apart from their normal applications to relieve
pains (Tramadol and Codeine), cough (Codeine) or as sedative (Flunitrazepam). High doses could
induce inflammatory and acute phase responses.
Aim and Objectives: This work was designed to determine the Immunological Effect of low and
High Doses of Tramadol, Codeine and Flunitrazepam on fasting Plasma Total Bile Acid,
Cortisol(Anti-inflammatory Agent) and Cortisol Binding Globulin (Acute Phase…
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Abstract: Gluconeogenesis involves formation of glucose from the breakdown of
protein to form glycogenic amino acid and lipid such as triglyceride to generate
glycerol which is further utilized for the formation of glucose. Cashew (Anacardium
occidentale) leaf has some non-scientific but traditional health benefit claims such
as in the treatment of diabetes and hypertension. This work was designed to
determine the evidence of Gluconeogenesis in rabbits given ypung cashew leaf
extract using Plasma Value of Cortisol, Glycerol, Cortisol Binding Globulin READ MORE Download Staff Profile      

Abstract: Inflammatory response is a form of immune response which could be
caused by infectious agents and toxic chemicals. Cnidoscolus aconitifolius leaf
extract contains phytonutrients such as protein, vitamins, calcium, and iron; and is
also a rich source of antioxidants which could be attributed to the traditional and
scientific claims in the treatment of anaemia. This work was designed to determine
possible pro and anti-inflammatory responses in the traditional application of raw
liquid extract of Cnidoscolus aconitifolius leaf (iyana ipaja-chaya)…
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Abstract
Alloimmunisation occurs when an antigen is introduced into an immune-competent host.
This commonly occurs following transfusion of blood or in pregnancy, when red cells
that bear antigens absent in the individual's blood enters the circulation. Five patients’
blood samples were brought for compatibility testing which includes blood grouping,
antibody screening and identification in the event of positive screening and crossmatching
with the available blood in the bank for transfusion. This narrative review
emphasises the benefit and criticality of comprehensive…
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ABSTRACT
Study Background: Plasma IL-2 and IL-10 are cytokines for immuno regulation and immuno
modulation in infectious diseases. IL10 inhibit synthesis of IFN gamma, IL-2, IL-3, TNF. Plasmodium
infection is associated with reproduction of cytokines for innate and acquired immunity.
Aim and Objective: This work was designed to determine variations in plasma IL-2 and IL-10 in
relationship with plasmodium parasite density.
Materials and Methods: Out of one hundred and sixteen (116) initially recruited only fifty
Plasmodium infected female and male…
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ABSTRACT
Study Background: Possible metabolic disorders of lipid, carbohydrate and protein are associated
with Diabetes mellitus which may include complications such as retinopathy considering the
pathophysiology of this metabolic disease.
Aims and Objectives: This work was designed to determine apolipoproteins (ApoA, ApoB), Total
cholesterol (TC), Total Triglyceride (TG), Low-density lipoprotein (LDL-C), Very Low-density
Lipoprotein (VLDL), High-density Lipoprotein (HDL-C) in Diabetes mellitus patients with or without
retinopathy.
Materials and Methods: 261 subjects were recruited for this study from the Medical outpatient…
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Background: Raw cucumber (Cucumis sativus) fruit juice contains phytochemicals and phytonutrients of antioxidative bioactivities while
overdose of amoxicillin could bring about drug-induced toxicity and oxidative stress. Malondialdehyde (MDA) is an oxidative index while
catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) are scavenging antioxidants. This work was therefore
designed to determine the scavenging antioxidative bioactivities of cucumber (C. sativus) fruit juice in rabbits overdosed with amoxicillin.
Methods: Fifteen rabbits of the same sex divided into three groups of 5…
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Introduction: Malaise involves general discomfort, uneasiness, or pain which could indicate microbial infection or other diseases which could
be as a result of immune response. Methods: The study population was 200 malaise anicteric hepatitis B surface antigen (HBsAg)?seronegative
patients (females – 100; males – 100) aged 5–76, and 111 apparently healthy anicteric nonmalaise age?matched subjects who were
HBsAg?seronegative (females – 56 and males – 55) were recruited as test and control subjects, respectively. Immunochemical assay of
anti?HBe, anti?HCV, HBsAg, and…
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Introduction: Guava leaf contains low calorie, vitamins, minerals antioxidants, polyphenolic, and flavonoid compounds which may play
important role in prevention of cancers, aging, cell differentiation, apoptosis and may also have immune enhancing properties while ibuprofen
is a nonsteroidal anti inflammatory drug commonly used to relief pain. It reduces hormones that cause inflammation and pain in the body.
This project work was therefore designed to evaluate the plasma level of pro (tumor necrosis factor alpha (TNF?)) and anti inflammatory
(interleukin 4…
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Study Background: Tumor necrosis factor?alpha (TNF??) is a proinflammatory cytokine which worsen
disease, interleukin?4 (IL?4) is an anti?inflammatory cytokine that enhance healing process while complement
4 mediates inflammation. Plasmodiasis and lymphatic filariasis can generate immune responses involving
cytokines and complements.
Aim and Objective: This work was designed to determine plasma level of TNF??, complement 4 (C4), and
IL?4 in Plasmodium co?infection with filariasis.
Materials and Methods: The test individuals recruited for this study include microfilaria monoinfected
patients (30), Plasmodium monoinfected…
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Study Background: Moringa oleifera, (miracle tree), has been used in the treatment of numerous diseases.
Moringa has been the subject of intensive scientific research; however, there have been scanty information
on its sub-acute effect on the kidneys.
Aims: This work was done to investigate the histological and biochemical effect of M. oleifera on the heart
and kidneys of adult Wistar rats.
Settings and Design: Twenty-eight adult healthy rats were used for this study. The rats were divided into 4
groups…
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Objectives: The objective of this study was to determine the possible inflammatory responses in hypercholesterolemia patients receiving treatment using raw liquid extract of young cashew leaves in some herbal homes in Nigeria.
Methods: Hypercholesterolemia patients (27: Aged 31–53 years; female - 10 and male - 17) 20 herbal homes in Saki-West, Saki-East, and ATISBO local governments constituting a Federal constituency in Nigeria, and non-hypercholesterolemia apparently healthy participants (50: Aged 20–64 years; female - 25 and male - 25) were recruited…
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Study Background: Trypanosoma cruzi and Toxoplasma gondii parasitic infections in human immunodeficiency
virus (HIV)?positive patients could accelerate the progression of HIV infection, which may result into
immunosuppression due to immune responses involving cytokines and CD4 + cells.
Aim and Objective: This work was designed to determine the immunochemical evidence of T. cruzi and
T. gondii parasitic infections in HIV/acquired immunodeficiency syndrome subjects in relationship with the
CD4+ count.
Materials and Methods: Fifty HIV?positive subjects (25 females and 25 males) aged…
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ABSTRACT
Background and Aim: Raw Cucumber (Cucumis sativus) fruit juice contains substances
of health promoting bioactivities. Plasma iron is stored in the liver and blood cells. Platelets
are blood cells involved in blood clotting for homeostasis while haemoglobin (found on red
blood cells) concentration is an index of anaemia and polycythemia. This work was therefore
designed to assess plasma iron, feritin, blood platelets and hemoglobin concentration in
rabbits given amoxicillin overdose supplemented with raw cucumber fruit Juice. Methods:
Fifteen rabbits…
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ABSTRACT
This study aimed at assessing knowledge of HIV/AIDS among residents of three
rural communities in Nigeria. A total of 371 persons residing in selected rural
communities were recruited for this study. A structured questionnaire was used
to collect data from all participants. Results of the study showed a generally
high level of awareness of HIV/AIDS in all communities surveyed. However,
among study participants, knowledge of mode of prevention and management
of HIV infection was poor as was knowledge of…
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Summary: World Health Organisation estimated that about 80% of Africans use herbal remedies for illness. Human immunodeficiency virus (HIV) infection which was believed to have no cure led many HIV patients to source for alternative or complementary therapy. A structured questionnaire was administered to 640 HIV patients in selected Nigerian HIV/AIDS clinics from 2009 to 2011 to assess their attitudes to the use of herbal remedy. Six hundred and ten (610) of the respondents were diagnosed by medical doctor and…
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a b s t r a c t
Background: The aim of this study was to assess public and private medical diagnostic laboratories in
Nigeria for the presence of biosafety equipment, devices, and measures.
Methods: A total of 80 diagnostic laboratories in biosafety level 3 were assessed for the presence of
biosafety equipment, devices, and compliance rate with biosafety practices. A detailed questionnaire and
checklist was used to obtain the relevant information from enlisted laboratories.
Results: The results showed the…
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UPTAKE OF HIV, HBV AND HCV TESTING SERVICES AMONG MEDICAL LABORATORY SCIENTIST IN NIGERIA

Abstract
Background: Human immunodeficiency virus (HIV) prevalence is high among rural dwellers and pregnant women. Aims:
This study aims to determine the prevalence of HIV and anemia among pregnant women attending antenatal clinic in rural
community of Okada, Edo State, Nigeria. Patients and Methods: Anticoagulated blood and sera samples were obtained
from 480 women consisting of 292 pregnant and 188 non-pregnant women. Antibodies to HIV were detected in the sera
samples and hemoglobin concentration of the anticoagulated blood specimens were…
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Objective: Hepatitis B virus (HBV) is not uncommon among persons infected with human immunodeficiency virus (HIV). Severity of HBV infection and treatment outcome are associated with specific HBV genotypes. No study has reported the types of HBV genotypes circulating among HIV-infected subjects in Nigeria. This study was designed to determine the prevalence of HBV, as well as its genotypic distribution among HIV-infected subjects in Benin City, Nigeria.
Methods: Whole blood was collected from a total of 564 HIV-infected and 250…
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Abstract
Objective: To determine type and frequency of omission of relevant
data on laboratory request forms at a rural tertiary Hospital in
Nigeria.
Methods: A total of 2,362 laboratory request forms sent to the
Pathology Department of Igbinedion University Teaching Hospital
Okada within a 10 month period were scrutinized for specifi c
parameters. The forms were evaluated to determine what section
was incorrect and/or incomplete and the frequency of such errors.
Results: Data mostly omitted was patient’s age, observed in…
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Lassa fever is endemic in west Africa. Persons at greatest risk are those living in rural
areas with poor sanitary conditions and overcrowding. Against this background, this
study aimed at assessing public awareness of Lassa fever among residents of three rural
communities in Edo State, Nigeria. A total of 380 persons resident in rural Okada,
Ogbese and Utese communities of Edo State, Nigeria were enrolled for this study. Age
range of participants was between 15 and 69 years. A structured…
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ABSTRACT
Background: This study aimed at determining the prevalence of malaria and anemia among children
in rural community of Okada, Edo State Nigeria, as well as to assess the level of use of Insecticide
treated bed nets and its impact on prevalence of malaria and anemia among study population.
Methods: Thick blood films from 226 children with signs and symptoms of malaria in Okada community
were stained and examined for presence of malaria parasites. Hemoglobin concentration of
all children was…
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It was estimated by World Health Organisation that about 80% of Africans used herbal remedies for
illness and HIV infection has no cure led many HIV patients to source for alternative or complementary
therapy. A structured questionnaire was administered to 528 medical practitioners in Nigeria health
institutions that attended national conferences on HIV/AIDS 2008 to 2009 to assess their attitudes to the
use of herbal remedy by HIV patients. 108 medical doctors, 304 nurses, 92 medical laboratory staff and
24…
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Abstract
The use of Nigella sativa concoction is very popular for treatment of different illnesses and its role on opportunistic organisms in Human
Immunodeficiency virus (HIV) infection required antimicrobial investigation. Against this background this study aimed at determining the
antimicrobial effect of Nigella sativa concoction on clinical isolates (Staphylococus aureus, Escherichai coli, Streptococus feacalis and
Candida albicans) obtained from HIV infected patients in Nigeria using the Agar disc diffusion and dilution methods. All clinical isolates
showed varying degree of susceptibility…
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Abstract
Research in human malaria disease has consistently been hindered in developing countries where this disease is
endemic, due to the prohibitive cost of constructing and maintaining currently available experimental mouse
models. Our goal, therefore, was to develop a cost-effective mouse model that may be used as research tool for
studying human malaria disease. Plasmodium falciparum-infected human blood samples were cultured invitro for
92 hours, and invivo malaria infection was induced by intraperitoneally injecting 0.5ml of the Plasmodium
falciparum cultures…
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Abstract Introduction
Hand hygiene is a very important procedure in Normal hand flora and contamination have
infection control. Washing agents commonly in use been implicated in many diseases thus causing major
were investigated for their effectiveness in reducing problem to the world for a long time until the discovery
hand floral and cotton towel was used as drying agent. of antibiotics (penicillins) in 1940's. This brought a
Agents studied include; water alone, carex soap, dettol, relief until the development of…
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Abstract Introduction
U rinary schistosomiasis is endemic in Nigeria Urinary shistosomiais is a major public health
and represents a significant public health challenge problem in developing countries of the world. It is
especially among inhabitants of rural areas. Against reported to be endemic in Africa, especially among
this background, this study aimed at determining the residence of rural communities1 . Urinary
prevalence and associated risk factors of urinary schistosomiasis is endemic in Nigeria1, 2, 3. Urogenital
schistosomiasis among children in…
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Abstract
Introduction: Seasonal variation in immunity has been found in healthy individuals and in association with some diseases. Data on seasonal prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is sparse. This study aimed at determining the seasonal seroprevalence of HBV and HCV infections among human immunodeficiency virus (HIV)-infected patients in Benin City.
Material and methods: A total of 1,177 HIV-positive and 503 non-HIV-positive patients were recruited for this study. Venous blood was collected from all…
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ABSTRACT
Aim: To study characteristics of pulmonary tubercu- losis amongst patients attending chest clinics in Benin City. Materials and Methods: A total of 816 subjects comprising of 563 (69%) males and 253 (31%) fe- males were enlisted for this study. Sputum specimen and blood were collected from all subjects. Acid al- cohol fast bacilli from sputa were examined using the Ziehl Nelson staning technique. Hemoglobin concen- tration was determined using the method described by Dacis and Lewis. Result: Pulmonary tuberculosis…
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Background: Trichomonas vaginalis infection is associated with adverse
reproductive outcomes and an increased risk for HIV transmission. Data on the
prevalence of trichomoniasis among women in rural Nigeria are sparse. Against
this background, this study aimed at determining the prevalence and associated
risk factors for T. vaginalis infection among women of reproductive age in rural
Okada community of Edo State, Nigeria. Materials and Methods: A pair of
high vaginal swabs was collected from 311 women (consisting of 217 pregnant
and…
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Study Background: Moringa oleifera, (miracle tree), has been used in the treatment of numerous diseases.
Moringa has been the subject of intensive scientific research; however, there have been scanty information
on its sub-acute effect on the kidneys.
Aims: This work was done to investigate the histological and biochemical effect of M. oleifera on the heart
and kidneys of adult Wistar rats.
Settings and Design: Twenty-eight adult healthy rats were used for this study. The rats were divided into 4
groups…
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Background: The expression of ABO blood group antigens on red cell surface and a variety of
human cells, tissues and fluids is well documented. Studies in the recent times have reported
association between these blood group antigens and some disorders in man. Cancer,
Cardiovascular disease and infection are some of the disorders reported. The interplay has given
rise to the assertion that ABO blood group system has extended its clinical significance beyond
the natural frontier of transfusion Science. This narrative…
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Pancytopaenia is the reduction or deficiency of all the three cellular components (Leucocyte,
PHeamoglobin and platelet concentration respectively) of blood. This is often found as a result of chemotherapy, infections and bone marrow failure.The study aims to determine the
prevalence of pancytopenia among HIVpatients.Two hundred subjects were studied which comprised of
100 HIV positive subjects, 50 were on ART with 37(74%) females and 13(26%) males while 50 were
ART naive with 28(56%) females and 22(44%) males attending ARTclinic in General…
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reservedAbstract Patients confirmed to be seropositive for human immunodeficiency Virus (HIV) infection by Western blot technique attending Baptist Medical Centre, Saki, Oyo state-Nigeria were studied; including 30 males; 30 females; 20HIV mono-infected, 20HIV-HBV co-infected, 20HIV-HCV co-infected subjects aged 16 to 65 years. Age and sex matched apparently healthy HIV, HCV and HBV seronegative, subjects (N=50) consisting of 25 (50%) males and 25 (50%) females were recruited as controls. Plasma ALT, AST and Total Bile Acids were determined in the subjects…
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A NOTE ON THE FREQUENCY OF ABO AND RHESUS BLOOD GROUPS IN DIABETES PATIENTS

CHOLESTEROL LOWERING EFFECT OF MALARBA SPINACH (AMUNUTUTU) ON EGG YOLK INDUCED HYPERCHOLESTEROLAEMIC RABBITS

THE IMMUNOCHEMICAL STATUS OF OF PATIENTS WITH ABNORMALLY RAISED BILE ACID RECIEVING TREATMENTS IN HERBAL/TRADITIONAL HOMES OF SOME RURAL COMMUNITIES IN NIGERIA 

SCAVENGING AND ANTIOXIDANT BIOACTIVITIES OFCUUMBER (CUCUMIS SATIVIS) FRUIT JUICE IN RABBITS TREATED WITH AMOXICILLIN

COMPARATIVE PATTERN OF THE FREQUENCY OF PLASMODIUM FALCIPARIUM, HOOKWORM, AND SCHISTOSOMA HAEMATOBIUM PARASITIC INFECTIONS AMONG THE ANAEMIC CHILDREN AGED 1-9YEARS IN RURAL NIGERIA

 COMPARATIVE STUDY OF THE DEGREE OF HAEMOLYSISIN hbSS IN NON CRISIS STEADY STATE AND hbSC DISEASE PATIENTS IN CRISIS

DIABETES MELLITUS AND HYPERTENSION: A STATISTICAL APPRASIAL

HYPERLIPIDEMIC EFFECT OF PERCSA AMERICANA (AVACADO) SEED EXTRACT ON FRUCTOSE INDUCED HYPERLIPIDEMIA IN ALBINO RATS

Study Background: Trypanosoma cruzi and Toxoplasma gondii parasitic infections in human immunodeficiency
virus (HIV)?positive patients could accelerate the progression of HIV infection, which may result into
immunosuppression due to immune responses involving cytokines and CD4 + cells.
Aim and Objective: This work was designed to determine the immunochemical evidence of T. cruzi and
T. gondii parasitic infections in HIV/acquired immunodeficiency syndrome subjects in relationship with the
CD4+ count.
Materials and Methods: Fifty HIV?positive subjects (25 females and 25 males) aged…
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PATTERN OF URINARY EXCRETION OF SCHISTOSOMA HAEMATOBIUM EGGS BY INFECTEDSUBJECTS AT ATISBO LOCAL GOVERNMENT AREA OF OYO STATE, NIGERIA

THE BIOCHEMICAL, HAEMATOLOGICAL AND VIRAL SEROLOGICAL PATTERN OF MULTIPLE MYELOMA PATIENTS 

Abstract
Long-term/chronic insomnia occurs in patients for over one month; it can affect the functions of the immune system and responses, which may
involve cytokines. The aim was to determine alterations of Tumor necrosis factor alpha (TNF-alpha) and IL-10 cytokines in long-term insomnia.
Thirty-three long-term/chronic insomnia patients (male, 22; female, 11) aged 47-61 years were initially recruited. Seven of them who were
infected with microbial agents were excluded from the study. Of the 26 free of infectious agents only 21…
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Abstract
Diabetes mellitus can induce release of free radicals and oxidative stress, which can trigger production of cytokines. Vernonia amygdalina has
antidiabetic activity due to its phytochemical constituents. This work was designed to determine possible immunological alterations in the
plasma levels of TNF-? and Interleukin-10 (IL-10) in the traditional application of V. amygdalina (Ewuro) leaves in the treatment of diabetes mellitus.
The study populations include all 33 diabetes mellitus patients (51-67 years; male, 21; female, 12) who had not commenced…
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THE FREQUENCY OF HAEMOGLOBIN TYPES (BASED ON ELECTROPHORECTIC PATTERN) IN NIGERIA: A CASE STUDY OF OKE-OGUN AREA OF OYO STATE

Background: Moringa oleifera, otherwise referred to as a miracle tree, has been used in the treatment of numerous diseases. Moringa has
been the subject of intensive scientific research; however, there has been scant information on its sub?acute effect on the kidneys. This work
was done to investigate the histological and biochemical effect of M. oleifera on the liver and lungs of adult Wistar rats. Twenty?eight adult
healthy rats were used for this study. The rats were divided into four groups…
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Background: Moringa oleifera, otherwise referred to as a miracle tree, has been used in the treatment of numerous diseases. Moringa has
been the subject of intensive scientific research; however, there has been scant information on its sub?acute effect on the kidneys. This work
was done to investigate the histological and biochemical effect of M. oleifera on the liver and lungs of adult Wistar rats. Twenty?eight adult
healthy rats were used for this study. The rats were divided into four groups…
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Background: Moringa oleifera, otherwise referred to as a miracle tree, has been used in the treatment of numerous diseases. Moringa has
been the subject of intensive scientific research; however, there has been scant information on its sub?acute effect on the kidneys. This work
was done to investigate the histological and biochemical effect of M. oleifera on the liver and lungs of adult Wistar rats. Twenty?eight adult
healthy rats were used for this study. The rats were divided into four groups…
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Abstract
Background: HTLV type I/II is a blood borne infection that can be transmitted via blood
transfusion.
Objective: To determine the seroprevalence of human T – lymphotropic virus among blood donors
in Osogbo, Nigeria.
Methods: Diagnosis of Human T. Lymphotropic virus antigen was carried out on 372 serum
samples among blood donors who visited the blood bank/transfusion unit of Ladoke Akintola
University of Technology Teaching Hospital and Our Lady of Fatima Catholic Hospital, Osogbo
between January and July 2008 using…
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ABSTRACT
Background: Hepatitis C Virus (HCV) is an agent of Transfusion Transmissible Infection (TTI) which
serves as a threat to blood safety and sufficiency of blood and blood products supply.
Objectives: This study aimed at determining the distribution patterns of HCV among potential blood donors
in a private Blood Bank in Osogbo, Nigeria.
Materials and Methods: Over a period of 6 months, 290 consenting prospective blood donors were
recruited for this study by convenient sampling technique. Pre-test counseling was done,…
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The aim of this study was to determine the frequencies of ABO Blood groups and haemolysins
(? and ß) in Osogbo metropolis. Seventeen thousands, nine hundred and thirty one subjects
(Age?18) who consented to donating blood for transfusion and/or blood group determination
were included in this study. About 5mls of blood were collected into plain bottles from each
subject. Cells and sera grouping were subsequently carried out after clot retraction. Blood
group O individuals have the highest frequency (53.6%) followed…
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Introduction
Medical laboratory science has been defined by the
Medical Laboratory Science Council of Nigeria
(MLSCN) Act 11 of 2003 as the practice involving
the analysis of human or animal tissues, body fluids,
excretions, production of biologicals, design and
fabrication of equipment for the purpose of medical
laboratory diagnosis, treatment and research1.
Quality practices in medical laboratory service are of
paramount importance in health care delivery

Aim: One third of HIV patients are co- infected with HCV. As HIV patients live longer this coinfection
and its complications such as liver cirrhosis, hepatic carcinoma, metabolic syndrome are
emerging as major manifestations of the disease that need to be dealt with promptly in order to
avoid a reduction of the positive effects of highly active antiretroviral therapy (HAART) on
HIV/AIDS introduced in 1996. Another system that could be affected by co-infection is the skeletal
system. It has been…
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ABSTRACT
Compliance of 21 private medical laboratories in Osun State with ethical and other professional was
assessed by the authors' pre and post inspection by the Medical Laboratory Science Council of Nigeria
(MLSCN). Laboratory environment, personnel, equipment and adherence to Standard Operating Procedures
(SOPs) were used as indicators and the results obtained were compared. Thirteen (62 %) was found to have
conformed to environmental specifications before the MLSCN's inspection. This rose to 84% and 89% a month
and 6 months…
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Background: In the north central Nigeria, observed haemoglobin concentration is often
used to determine the packed cell volume of patients, especially by many laboratories
that cannot afford the cost of micro-haematocrit centrifuge.
Aim: The study was carried out to determine the accuracy of 3-fold haemoglobin
conversion to haematocrit level in anaemic conditions.
Materials and Methods: The study was conducted on 580 symptomatic (febrile)
patients and 810 subclinically anaemic subjects attending some selected private medical
laboratories, hospitals and clinics in Kuje…
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Abstract: Atherogenic cardiovascular risk assessment is important in the
management of dyslipidaemia associated with antiretroviral therapy (ART).
Generally, Castelli?s Risk Index (CRI), Atherogenic Index of Plasma (AIP) and
Atherogenic coefficient (AC) are becoming useful indices as risk predictors for
cardiovascular disease (CVD). We studied the importance of these indices in
identifying at-risk HIV individuals receiving treatment. Eighty (80) HIV-patients
comprising treatment (n=40) and treatment-naïve (n=40) groups with age- and sexmatched
were enrolled. Traditional lipid parameters {Total cholesterol (TC),
Triglycerol (TG),…
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Abstract
Background: Previous reports showed lack of consensus on the possible etiology of coronary artery disease (CAD) between
HIV-treatment with highly active antiretroviral therapy (HAART) and HIV-infection in particular. The aim of this
study was to find out correlations of HIV-treatment and HIV-infection with CAD risk.
Method: One hundred and twenty (120) participants involving HIV-patients on treatment (n = 40), treatment-naïve (n =
40) and equal number of age- and sex-matched controls were enrolled. The total cholesterol, triglycerides and lipoprotein READ MORE Download Staff Profile

ABSTRACT
PURPOSE: PMTCT interventions, especially initiation of Highly active antiretroviral therapy (HAART) has modified the
natural history of HIV infection by reducing both peripartal and neonatal HIV infections, but the pattern of the immunologic
responses of these pregnant women to HAART remains speculative. It is hoped from this study, to describe the pattern of
immunologic response of naïve, HIV positive pregnant women on their first initiation on HAART.
METHODS: This study described the pattern of CD4 changes observed in freshly…
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The study was conducted to investigate the safety of combined extracts of Bryophyllum
pinnatum (family: Crassulaceae) and Aloe barbadensis (family: Xanthorrhoeaceae) in
rats. Forty rats were randomly selected and divided into four groups. Rats in groups I
were administered with placebo as the control animals, while rats in groups II, III and IV
were administered with aqueous extracts at 25mg/ml, 50mg/ml and 100mg/ml
respectively for 28 days. Five milliliter (5ml) of blood was collected from either the ocular
vein or…
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Aims: A commercial rapid test kit for anti-Hepatitis C Virus (anti-HCV) detection was
evaluated and compared for diagnosis of hepatitis C by detection of immunoglobulin
G(IgG) antibodies against a third generation Enzyme Immunoassay(EIA) as gold
standard.
Methodology: A total of 560 patient serum samples were subjected to rapid screening
with rapid test (immunochromatographic) strip supplied by Global Diagnostics and
commercially prepared IgG capture EIA by DIA.PRO, Italy.
Results: Of the 560 samples, anti HCV was detected in 31(5.54%) by ELISA,…
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Osogbo metropolis, with the aim of determining the degree of iron deficiency anaemia in the study population. One hundred confirmed anaemic and recently un-transfused patients with haemoglobin concentration level less than 8 g/dL were selected from two major hospitals in Osogbo. Participants were within aged 6 months – 65 years of both sexes. The parameters estimated were haematological indices using automation (Humancount machine). Serum iron and ferritin were also estimated using Atomic Absorption Spectrophotometry, blood film was made for every…
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Abstract
Dengue virus is one of the causative agents of viral haemorrhagic fever, which is transmitted primarily
through Aedes mosquitoes. Transmission of the virus through non-vector sources had been proven, although,
it is the most common arthropod-borne viral infection in human. This study was carried out to determine the
prevalence of Dengue Virus amongst voluntary blood donors in Osogbo, southwest Nigeria. Ninety one
voluntary non-remunerated donors that satisfied donor suitability criteria in Nigeria; having been considered
fit based on physical…
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Abstract. Dengue fever is becoming one of the major public health problems in the world and
its distribution has been premised on the migration of people from infected regions. This
study was carried out to determine the prevalence of dengue virus IgG antibody among the
patients with febrile conditions attending health facilities in Osogbo metropolis, Southwestern
Nigeria. The blood samples collected between July and September, 2014 were tested for
Plasmodium falciparum and the sera were subsequently subjected to Enzyme Linked READ MORE Download Staff Profile

THE EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL TRHERAPHY ON CD4 COUNTS AND BODY WEIGHTS IN HIV/AIDS PATIENTS IN SOUTH WEST NIGERIA

Hospital and community acquired infections, continue to be a threat to public health, causing
morbidities and mortalities. This survey was carried out to determine the prevalence of
Enterobacteriaceae in nosocomial and community acquired infections among adults in LAUTECH
Teaching Hospital in Osogbo southwestern Nigeria. Two hundred and forty isolates from General Out
Patient Department (GOPD) and two hundred and forty isolates from different wards (Surgical, Medical,
Gyneacological, Pediatric, Burn Unit and Ear, Nose and Throat wards) of the hospital were…
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Objective: HIV and HCV share routes of infection. Co-infection and its complications are therefore emerging as a major concern as patients on HAART have longer life expectancy. These complications have been well documented. It is necessary to determine in our environment what epidemiological factors are associated. This is expected to improve treatment protocols leading to increase quality of life and prolonged lifespan. Liver enzymes may be useful to monitor therapy. Materials and Methods: This is a prospective study. Seventy age…
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Summary
This prospective study of parturients at a tertiary health institution in south-western Nigeria aims to identify the incidence,
severity and obstetric factors predisposing to feto – maternal haemorrhage (FMH) in our population. The exclusion criteria
were haemoglobinopathy and patient’s refusal of consent to participate in the study. The prepared slide was processed as in
the acid elution test described by Kleihauer – Betke. The FMH was calculated using Mollison formula (Mollison 1972).
Baseline data included maternal biodata, blood group,…
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a b s t r a c t
Aim: This studyisthefirstattemptconductedtodeterminetheco-infectionratesofHepatitisCvirus
among peoplelivingwithHIV/AIDS(PLWHA)inourhospital.Thisisexpectedtoleadtoimprovementin
treatment protocols.
Background: Co-infection ofHepatitisCvirusinfectionandHIV(HumanImmuneDeficiencyVirus)infec-
tion isnottobeunexpectedastheyshareroutesofinfection.Thedetectionofsuchpatientsisparticularly
important asthetreatmentmayinvolvelifethreateningdruginteractions.Thiscouldresultinshorter
life expectancyofthepatients.
Materials andMethods: This isaprospectivestudy.Atotalof280subjectslivingwithHIV/AIDSwere
recruited intothisstudy.Seraoftheparticipantsweresubjectedtoanti-HCVantibody(IgG)screening
using thirdgenerationELISAkitfromDIA.PRO,Italy.TheprevalenceofHCVwasdeterminedandbar
charts andtableswereutilisedtodepicttheprevalenceratesofvariousgroups.
Results: Sixty five(23.2%)oftheparticipantswerefoundtobeco-infected.Noassociationwasestablished
between age,sex,partnersstatus,previoustransfusion,andnumberofpartners.
Conclusion: The prevalenceof23.2%forHCVamongPLWHAreportedforthiscommunityisalarming.
More focusshouldbedirectedonmanagementofHCVcomponentofcoinfectionthanitisdonenow.
Further studiesarerecommendedemployingmoleculartechniquestodeterminesubtypesofHCVthat
may bepredominantandwhythisfigureofco-infectionissohighinthestudylocation.

Abstract
Background: The lives of patients living with HIV/AIDs have improved in terms of
longer life expectancy and quality. This has seen the emergence of complications of
the disease and the drugs such as metabolic syndrome and re-emergence of tuberculosis.
Co-infection with other viruses especially the hepatic viruses has also become a
major source of concern. The aim of this research is to determine the incidence of
hepatitis B and E among this group of patients. Methods and Findings: Blood…
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Social lifestyle plays a significant role in the transmission of human immunodeficiency
virus (HIV). Hence, abstinence and faithfulness are important for preventing
HIV transmission.
This study aimed to determine the prevalence of HIV antibodies among Muslims
in Osun state, Nigeria.
A total of 1554 Muslims who attended mosques for worship and provided consent
were recruited for this study. Relevant data were obtained using a pro forma
designed for this purpose. Blood specimens were collected for HIV screening
using Determine, Unigold,…
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ABSTRACT
Background: The influences of tribes on coagulation profile have not been sufficiently investigated. However, Genetic factors contribute to the inter individual variation of blood coagulation protein levels (de Lange et al., 2001). This study was aimed to assess some coagulation profile on 420 subjects, age range 18-84years old, consisting of 60 subjects each from the different tribes (Igbo, Yoruba, Hausa, Ibibio, Ijaw, Urhobo and Efik) males and females all residing in Nnewi town, Anambra state Nigeria. Prothrombin Time (PT),…
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ABSTRACT
Infection with Hepatitis C Virus (HCV) is a public health problem. Worldwide, there are about 170 million people infected with
HCV. HCV is transmitted through sex and use of contaminated sharp objects during tattooing or intravenous drug abuse. These
routes make youth to be more vulnerable. Transfusion and mother to child transmissions are also documented modes. This
study was carried out to determine sero-prevalence of hepatitis C virus infection among in school youth at Achievers University,
Owo in southwest…
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COMPROMISE IN RAPID KITS MAKES IT UNSUITABLE FOR BLOOD TRANSFUDION SAFETY

Abstract Background: Drepanocytosis (sickle cell anaemia) is a genetic disorder that causes stiff, rod-like sickle-shaped haemoglobin in red blood cells (RBCs) and consequently poses serious health complications. We investigated in vitro anti-sickling potential of a novel polyherbal formula (MPF). Methods: Sickling of RBCs induced with 2%sodium metabisulphite (MBS) was followed by treatment with MPF mixtures in different saline concentrations (7mg/ml, 9mg/ml, 14mg/ml and 28mg/ml). The red cell morphology was examined microscopically. Percentage sickling was quantified 30-minute interval at 370C for…
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Abstract
Infectious agents and chemical substances can trigger the production and the release of cytokines.
To determine the pattern of infectious agents in herbal homes patients with elevated TNF? (? 5.0
pg/ml) in Saki – West-Nigeria. The subjects include patients with elevated TNF? (? 5.0 pg/ml) in 15
herbal homes(n=23 ; aged 5-69 years; males – 13 ; females – 10) and patients with elevated TNF? in
3 major hospitals (n = 32; aged 6 -67years; males – 12 ;…
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Background: Viral biomarkers in pulmonary tuberculosis (PTB) could be a primary or secondary viral infection to PTB which may depressed
immunity or make the patient susceptible to the secondary infection. Aim and Objective: This work was, therefore, designed to determine
frequency of anti?hepatitis C virus (HCV), hepatitis B envelope antigen (HBeAg), hepatitis B surface antigen (HBsAg), hepatitis B envelope
antibody (HBeAb), and human immunodeficiency virus (HIV)?1 p24 in newly infected Mycobacterium PTB patients. Materials and Methods:
Sixty newly infected Mycobacterium…
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Study Background: Toxoplasma gondii a protozoan and zoonotic infection can stimulate innate and adaptive immune responses. Aims
and Objectives: This work was designed to determine relationship between parasitic infection of T. gondii, interleukin?2 (IL?2), tumor
necrosis factor?alpha (TNF??), and Tryptophan and CD4+ count. Materials and Methods: A total of 150 individuals aged 21–73 years
(male: 100 and female: 50) were recruited from Saki?West, Saki?East, and ATISBO local governments of Nigeria. Plasma TNF??, IL?2,
Tryptophan, anti?hepatitis C virus (anti?HCV), hepatitis B…
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Urinary Schistosomiasis is a parasitic disease of public health importance in Africa affecting
children. It relationship with malnutrition is well pronounced in Nigeria and impairs growth of
the affected children or persons. This work investigates the nutritional status of children
infected with urinary schistosomiasis. The Anthropometric indices of the studied children
were determined according to standard procedures and related to intensity of Schistosom.
haematobium infection. The weight, height and Age were Anthropometric indices used in this
study. A total of…
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Platelet and Red Cell Indices of anti-Dengue IgM Negative Blood Donors in Owo, Southwest Nigeria

ABSTRACT
A cross-sectional study was carried out in Ilie community of Olorunda Local Government Area in Osun state, southwestern
Nigeria to comparatively evaluate the presumptive diagnosis of schistosoma infections using microscopy as gold standard. One
hundred and thirty seven consented primary school children aged 4 to 15 years were examined for presence of schistosome eggs.
The urine samples were analyzed with urinalysis strips for microhaematuria as indicators of presumptive diagnosis for urinary
schistosomiasis while fecal samples were analyzed with fecal…
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ABSTRACT
Purpose: Feto-maternal haemorrhage (FMH) is a complication of pregnancy and large FMH may lead to life-threaten- ing anaemia in the fetus or newborn. In addition, exposure of Rhesus (Rh) D negative women to small amounts of fetal Rh D positive red cells during pregnancy or delivery may result in sensitization with its attendant problems of isoim-munisation. In most cases, the cause of FMH IS unknown. Through this study, we sought to determine if placental weight & diameter have any…
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Background: Transfusion-transmissible infectious agents such as hepatitis B virus (HBV),
human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis are among the
greatest threats to blood safety for transfusion recipients and pose a serious public health problem.
This cross-sectional study was undertaken with the aim of determining the seroprevalence of
HIV, HCV, hepatitis B surface antigen (HBsAg) and syphilis and correlates the findings with
sex and age to ascertain the associations, if any, in the occurrence of the pathogens. READ MORE Download Staff Profile

Abstract
Introduction: To determine the possibility of utilizing total lymphocyte counts (TLC) instead of
CD4 counts in the initiation and management of patients with HIV on highly active antiretroviral
therapy (HAART). The commencement of HAART CD4 lymphocytes has been employed in the
management HIV. However it has been found that determination of CD4 counts is expensive and
somewhat laborious to perform in already overburdened healthcare systems especially in the developing
countries. Methodology: Five hundred and three (503) consenting patients already…
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