Ehebha S. E. Odokuma E.I. Cervical cytological patterns among staff of Delta State Aniversity, Abraka Nigeria

ORIGINAL ARTICLE

Cervical cytological patterns among staff of Delta State University, Abraka, Nigeria

ABSTRACT

Introduction: Cytological analysis has severally been demonstrated by many authors as a tool in the assessment of the uterine cervix. Indeed this inexpensive technique, developed by George Papanicolaou, is now widely accepted and used in achieving significant reduction in cervical lesions in several countries. Though…
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GSJ: Volume 6, Issue 12, December 2018, Online: ISSN 2320-9186
www.globalscientificjournal.com
EFFECTS OF CRUDE AQUEOUS EXTRACT OF
MORINDA LUCIDA LEAF EXTRACT ON THE
HISTOLOGY OF LIVER OF ADULT WISTAR RATS
(RATTUS NORVEGICUS).
O.O. Adeleye*1, A.A. Akande2, A.A. Odetola3, J.I.Ayanlade4
1,4Department of Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
2Department of Anatomy, Lead City University, Ibadan, Oyo State. Nigeria.
3Department of Anatomy, Edo University, Iyamho, Edo State. Nigeria.
(E-mail: funtoadeleye@gmail.com, Telephone no: +2348064019455)
Authors’ contributions
This work was…
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Abstract- This study investigates the various fetal presentations among women in Warri and the various predisposing factors which may have
possibly brought about these variations; the major positions considered were cephalic, breech and transverse, with the considered influencing
factors being gestational age of the fetus, maternal age, amniotic fluid volume, parity, and method of previous deliveries. A total of 105 ultrasound
fetal biometries with a total of 108 fetuses, between 15-40 weeks of gestational age, and maternal age between 19…
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ABSTRACT
Aim: The study investigated the modulating roles of ethanolic roots extract of
Crossopteryx febrifuga (CF) for its antihyperglycemic, antihyperlipidemic, glycosylated
hemoglobin effects and cytoarchitectural changes on pancreatic beta cells in alloxaninduced
diabetic rats
Study Design: Experimental diabetes using animal models.
Methodology: Twenty- Five (25) male albino rats were randomly divided into five (5)
experimental groups: control, diabetic, standard drug (glibenclamide 10 mg/kg body wt)
and C. febrifuga (375 and 500 mg/kg bwt) treated diabetic groups The animals in four…
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ABSTRACT
This study investigated the effect of ethanolic roots extract of
Pseudocecrela kotschyi on some hematological and biochemical
parameters in alloxan-induced diabetic rats. Twenty- Five (25) wistar
rats were randomly divided into five (5) experimental groups: control,
diabetic, standard drug (glibenclamide) and Pseudocedrela kotschyi
treated diabetic groups. The animals in four out of five groups were
fasted for 18 h and were made diabetic by injecting with a single dose
of alloxan (ALX) 150 mg kg-1. At the end of…
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within population, providing valuable insight into the dynamics of population structure. The present study, therefore aimed at
providing the percentage frequency of the ABO and Rhesus distribution pattern of adults who attended the Federal Medical
Centre Lokoja, Kogi State, Nigeria for record and health planning. The study was carried out on two hundred adults (77 male and
123 female). The blood samples were taken by cubital venepuncture and analysed using the agglutination method (Dacie and
Lewis 2001). Among the male…
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Abstract: The last decades have witnessed an upsurge of neuropeptides research. These substances regulate or
influence various functions in the body like appetite, water intake, learning and memory, adaptive responses to
environmental stress, thermoregulation and fever, social behaviour, and sleep. Kisspeptin (formerly known as
metastin) is a protein that is encoded by the KISS1 gene in the Anteroventral periventricular nucleus (AVPV)
and Arcuate nucleus (ARC) nuclei of the hypothalamus which was originally discovered in 1996 by Lee and
Welch while…
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ABSTRACT: The biological responses of Allium sativum (Garlic) have been largely attributed stimulation of
immune function and reduction of risk factors for cardiovascular diseases and cancer. The effects of Allium sativum
on blood cells and platelets was investigated in Wistar rats. The animals (105 – 158 g) were divided into three (3)
groups; the Group A served as the control received 1 ml of distilled water, Group B received 3.5 g/kg body weight of
garlic juice and Group C received…
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ABSTRACT
Objective: The study investigated the activities of antihypoglycemic and antihypolipidemic of ethanolic roots extract of Crossopteryx febrifuga (CF) in alloxan-induced diabetic rats.
Methods: Twenty male albino rats were randomly distributed to four groups; I, II, III and IV with each consisting of five animals received extracts as follows: Group I, C .febrifuga
(500 mg/kg bwt); Group II, C.febrifuga (250 mg/kg bwt); Group III, C. febrifuga (100 mg/kg bwt); Group IV, 0.5 ml (2% w/v) acacia solution and served as…
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ABSTRACT
Spermatogenesis is an extremely active replicative process capable of generating
approximately 1000 sperms a second with correspondingly high rates of mitochondrial
oxygen consumption by the germinal epithelium. This process generates reactive oxygen
species (ROS) through reactions with drugs and environmental toxins, or when the level of
antioxidants is diminished results in oxidative stress. Excessive production of free radicals
or ROS can damage sperm, testes and can cause serious chemical damage to
biomolecules (DNA, proteins, and unsaturated lipids) which ultimately…
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Abstract
A series of glycoprotein and glycolipids on red blood cell surface constitute blood group antigens. These are the ABO (A,
B, AB and O) and Rh blood groups which are the most important blood groups despite the long list of several other blood
groups discovered so far. The ABO and Rh blood groups vary worldwide and are not found in equal numbers even among
ethnic groups. Therefore, this study was aimed at having information on the distribution of ABO…
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ABSTRACT: The present study was designed to investigate the role of L-ergothioneine supplement against
cisplatin-induced reproductive toxicity in male wistar rats, regarding the antioxidant and cytoprotectant
property of this supplement, and redox indices generated by cisplatin administration during
administration.Twenty adult male wistar rats randomly divided into four groups (n=5) were used in this study
and subjected to treatment as follows; Group I (control) received 10mL/kg distilled water for 14days; Group II
(Cis alone) received a single dose of 7 mg/kg…
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ABSTRACT
The contraceptive effect of oral administration of ethanolic extract of Dioscorea villosa tuber for thirty days
on reproductive hormones of female albino rats was investigated. Twenty four female albino rats weighing
150-220g were completely randomized into four groups (A-D) comprising six rats each. Animals in Group A
(control) were administered 0.5ml of distilled water. Animals in groups B, C and D received 100, 200 and
400mg/kg body weight of ethanolic extract of Dioscorea villosa tuber respectively for 30 consecutive…
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ABSTRACT:
Background: Hibiscus sabdariffa is used for medicinal purposes, especially in alternative medicine. It
is a folk remedy for abscesses, cancer, cough, debility, dyspepsia, dysuria, fever, hangover, heart ailments,
neurosis, scurvy and strangury. This present study was carried out to investigate the anti-inflammatory activity
of methanolic extract of hibiscus sabdariffa in adult wistar rat.
Methods: A total of Twenty-five (25) of both sexes rats weighing between 180 - 200 g were randomly
divided into five (5) groups of five (5)…
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ABSTRACT
Introduction: Volatile organic compounds (VOCs) in paint are considered harmful to the
environment, especially for people who work with them on a regular basis. Aim: In this study,
we investigated the effect of VOCs in gloss paint, emulsion, and thinner on the testes of male
Wistar rats. Materials and Methods: Twenty adult Wistar rats (100–200 g) were assigned to
four (4) groups (A–D) of five rats each. Groups A (thinner), B (emulsion paint), and C (gloss
paint) were exposed…
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ABSTRACT
Aim: This study was carried out to investigate the role of coconut oil on
pentylenetetrazole (PTZ) induced convulsant activity in Wistar rats using the laboratory
model. Convulsant activity was achieved by injection of PTZ.
Study Design: The rats were divided into five groups. Group 1 served as control and
received distilled water orally. Group2 was a reference group and received only PTZ. The
remaining three groups (3, 4 and 5) were test groups and rats were given oral
administration…
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The role of adrenergic receptors in cortisol-induced hyperglycaemia is not well known. The present
study investigates the effects of adrenergic receptor blockers in cortisol-induced hyperglycaemia in the
common African toad (Bufo regularis). Each toad was fasted and anesthetized with sodium
pentobarbitone (3 mg/100 g i.p). The animals (control) received intravenous (i.v) injection of 0.7%
amphibian saline while animals (untreated) were given cortisol (20 ?g/kg). In pre-treatment groups,
animals received prazosin (0.2 mg/kg i.v), propranolol 0.5 mg/kg or combination of prazosin…
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The role of adrenergic receptors in cortisol-induced hyperglycaemia is not well known. The present
study investigates the effects of adrenergic receptor blockers in cortisol-induced hyperglycaemia in the
common African toad (Bufo regularis). Each toad was fasted and anesthetized with sodium
pentobarbitone (3 mg/100 g i.p). The animals (control) received intravenous (i.v) injection of 0.7%
amphibian saline while animals (untreated) were given cortisol (20 ?g/kg). In pre-treatment groups,
animals received prazosin (0.2 mg/kg i.v), propranolol 0.5 mg/kg or combination of prazosin…
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Abstract
Garcinia kola has been confirmed for spermatogenic and tissue enhancing effect of testis in male wistar rats. This study
was carried out to investigate the histological effect of ethanolic extract of Garcinia kola on Lead II oxide induced testicular
damage. Thirty five (35) adult male wistar rats were randomly selected into seven (7) groups n=5. Group A received 0.5 ml
saline solution, Group B received 100 mg/kg of Garcinia kola extract only, Group C received 5 mg/kg of Lead…
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ABSTRACT
Objectives: Male infertility caused by exposure to
heavy metals is a current global issue. Exposure to cadmium
chloride (CdCl2) negatively affects the male reproductive
system. Many infertile people, especially in developing
countries, resort to folkloric treatment. Plukenetia
conophora is used in Nigerian folk medicine to promote
fertility. This study investigated the effects of Plukenetia
conophora (PC) and 4H-Pyran-4-One 2,3-Dihydro-3,5-Dihydroxy-
6-Methyl (DDMP) on Wistar rats with cadmium
chloride-induced testicular damage.
Methods: Forty-two male Wistar rats (150-190g) were
divided into seven…
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Abstract
Background: The study was designed to investigate the effect of stem bark aqueous extract of Enantia chlorantha on the sperm
parameters and the histo-architecture of the testis of adult Wistar rats treated with lead (IV) oxide.
Methods: A total of 20 adult male rats weighing between 180 g-200 g were randomly selected into 4 groups (n=5). Group 1 was
giving only phosphate buffered saline; Group 2 was treated with 150 mg/kg body weight of the extract; Group 3 was…
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ABSTRACT
Leucocytosis, marked increase in the number of white blood cells (WBC) is a known physiological
response to trauma. In recent times, several studies have asserted the absence of this response in
Africans. In view of this, current study investigated the existence of, and prognostic implications of
post-traumatic leucocytosis amongst adult Nigerians with acute musculoskeletal (MSK) trauma. Two
hundred and twenty three (223) adult male and females (MSK traumatized) and fifty apparently
healthy volunteers (adults) were ethically recruited from the…
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Abstract
Background: Pre-marital screening programme is aimed at reducing the incidence of
hereditary and sexually transmitted diseases in the society. The study was carried out to
determine the types of tests done by churches in Oredo LOA, Benin City.
Methods: A descriptive cross-sectional study was carried out among all the 140 churches
in Ihogbe and Ogbe quarters in Oredo LOA of Benin-City, Nigeria.
Result: Out of a total of 140 churches studied through their church leaders, all of them
requested…
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Summary
Solitary plasmacytomas are defined as proliferation of monoclonal plasma cells without
evidence of significant bone-marrow plasma-cell infiltration. They are classified
according to location into solitary plasmacytoma of bone if they occur in bone, and
extramedullary plasmacytoma if they arise in soft tissues. They are more frequent in
males than females and have a peak incidence in the fifth and sixth decade of life.
Solitary plasmacytoma accounts for about 5% of plasma cell tumours. More than 80% of
extramedullary plasmacytoma…
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Abstract
Background: Human Immunodeficiency Virus/HfV) and Hepatitis B Virus(HBV)
infections are global viral diseases with various seroprevalence rates in different parts of
the world. They share similar modes of transmission and are very important in
Transfusion Medicine.
Aim/Objective: To determine the level of awareness and practice of HIV and Hepatitis B
virus screening among Niger-Delta residents.
Methodology: Semi-structured questionnaire was used to collect information from
residents in Benin and Warri towns of southern Nigeria.
Results: A total of 396 people…
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Abstract
Background: Carbon monoxide is a tastelessvodourless, colourless, non-irritating, and
poisonous gas produced by incomplete combustion of organic materials. It is particularly
dangerous as it cannot be detected by man's natural sense organs. There is hardly a
month without one or two newspaper reports of death attributed to carbon monoxide
poisoning.
Objective: To determine the students' knowledge about carbon monoxide poisoning, and
their ability to identify victims suspected of suffering from carbon monoxide poisoning.
Methodology: A descriptive, cross-sectional study was…
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Abstract
Background: The increased need of safe
blood and blood products and their
unavailability in hospitals remain a formidable
challenge faced by healthcare providers in
developing countries such as Nigeria.
Airn:To determine the level of awareness of
blood donation among tertiary institution
undergraduates in an urban setting of
Southern Nigeria.
Methodology: Semi-structured questionnaire
was used to collect information from
undergraduates of the University of Benin
and Delta State University both in southern
Nigeria. Data analysis was done using SPSS
software…
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Background: The study was conceived to
assess the seroprevalence of human
immunodeficiency virus among blood donors
living in Warri South South region of Nigeria.
The importance ofthis study is to highlight the
prevalence of HIV in different age groups of
blood donors.
Methods: This was a descriptive analysis of
the records ofa total of3518 blood donors for
the year 2002 to ascertain the age distribution
and the sero-positivity for the human
immunodeficiency virus. Descriptive
statistics was used to present the…
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Background: Blood saves lives only when
the blood itself is safe. The safety of blood
depends on the quality of its donor and these
donors can be categorized into commercial,
replacement and voluntary blood donors.
Aim and Objective: The aim of this study
was to determine the socio-demographic
factors and categories of blood donors in
Warri, Southern Nigeria.
Materials and Methods:A Semi-structured
self-administered questionnaire was used to
collect all necessary information from blood
donors.
Results: A total of 500 blood…
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Background: The blood of a pregnant
woman is quite unique with a lot of interesting
challenges. In non-pregnant women, certain
alterations in haematopoeitic systems call for
therapeutic interventions. In the state of
pregnancy, however, some of such changes
are regarded harmless because of reversal to
non-pregnant values after delivery. On the
other hand, management of some bloodrelated
pathologies in pregnancy puts the
healthcare provider at his/her wits end
because of the consideration of possible
effect(s) of any treatment modality on…
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SUMMARY
The case of a 54-year eld woman who never
knew she had sickle cell anaemia until she
presented with a two week history of
weakness, fever.loss of appetite. nausea, easy
fatiquability and upper abdominal pains is
presented. She was a known hypertensive and
peptic ulcer disease prior to presentation. Her
Peripheral blood film and haemglobin
electrophoresis confirmed diagnosis of sickle
cell anaemia. It is highlighted that while
diagnosis commonly occurs in childhood,
symptomatology of the disease can occur in READ MORE Download Staff Profile

SUMMARY
Objective: To determine the incidence and soclodemographic factors associated with
various adult leukaemia subtypes in a tertiary hospital in, Nigeria.
Patients and Methods: A total of 190 patients with a diagnosis of leukaemia seen OVf:T a
12-year period (1990.2002) at the University of Benin Teaching Hospital, Nigeria were
studied. They were analyzed in the context of gender, marital status, geographical abode.
educational and occupational status,
Results: There were 70 males and 120 females with a male-to-female ratio of 1:1.7. READ MORE Download Staff Profile

Abstract
Background: Petroleum exploration has been associated with diverse health problems in many parts of
the world. There are reports of increased incidences ofhaematological malignancies in the areas where
petroleum exploration is taking place. Petroleum exploration and exploitation has been ongoing in many
countries and people living in these areas have borne the brunt ofthe environmental and health devastation
taking place and efforts are not made to educate these people ofthe hazards they are encountering
Objective: The aim of this…
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ABSTRACT
Background: Idiopathic Myelofibrosis is a non-leukemic myeloproliferative disorder
characterized by generalized fibrosis of the bone marrow in association with
extramedullary haematopoiesis mainly in the spleen and liver. Prominent among its
laboratory features are the presence of tear drop red blood cells (dacryocytes) and
immature red blood and white cells (leukoerythroblasts) in the peripheral blood film.
Aim: The objectives of this paper are to present a case of Idiopathic Myelofibrosis without
the usual peripheral blood film picture and also to…
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ABSTRACT
Background: The higher prevalence of blood group 0 places more demand on it when compared
to other blood groups in developing countries. Group 0 blood is usually abused in hospitals with
the erroneous belief that individuals with blood group 0 are universal donors. Haemolysins are
IgG antibodies seen particularly in blood group 0 subjects and their demonstration in vitro helps
detect dangerous blood group 0 donors whenever such blood is to be given to non-O individuals.
Objective: The aims…
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AdescriPtive retrospctive study of the
pattern of children admitted between
ugust 2002 and January 2005
inclusive to the department of Paediatrics of
Central Hospital Ughelli, an urban community
in the oil rich Niger-Delta region of Nigeria was
done. Children between 2 months and 3 years
constituted 64.1% of the total admissions and
79% of those with severe anaemia that required
transfusion. The neonatal admissions was just
0.3% of the total admissions but the neonatal
transfusion was O.7% of the total…
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ABSTRACT
Background: Acquired Immunodeficiency Syndrome (AIDS) pandemic has become a major global
public health problem, the brunt of which is largely borne by communities in Sub-Saharan Africa.
Objectives: The aim ofthis review is to highlight and bring to the fore the peripheral blood and bone
marrow changes ofHIV and AIDS because many Hlv-infected persons may present with these changes
as more patients with this disease survive longer because oftherapy.
Methods: The review was sourced mainly by pubmed search using the…
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ABSTRACT
Background/Objective: In a rapidly developing world where conflicts are inevitable and accidents
and other forms of trauma are constantly encountered there is an increased need for blood transfusion
to keep victims ofthese events alive. As the need for blood increases, there is a corresponding decrease
in the amount of blood available for transfusion due to increased demand and a falling donor pool. In
addition, there are people who due to religious reasons abhor blood transfusion. The emergence ofthe
HIV…
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Abstract
Background: Churg Strauss syndrome is a medical
COIId-tionof unknoVin aetiology characterized by as/hma,
eosinophilia and finally vasculitis involving small vessels
in thelimbs and nasal sinuses aoo the lungs. The purpose
of this Tevie is to highlight the natural history of this
condifon, the pathogenesis, clinical features and
lteatmenl modalities available and the prognosis.
Methods: Literature on the subJect Vias reviewed using
manuallibrary search. articles injoumals, internet search
andconference abstracts. .
Result Churg Strauss syndrome has been reported to
be…
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Summary
Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder.
characterized by the presence of Philadelphia chromosome and affects a good number of
Africans and African-American population. The aim of this review is to highlight the
aetiophysiology, clinical/laboratory characteristics and treatment options, especially the new
and emerging treatment modalities of CML. The review was sourced mainly from internet
(pubmed). Relevant Oncology journals and textbooks of haematology were also consulted.
There are reported cases of relapse/resistance to imatinib which is the current…
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ABSTRACT
Background: Disseminated intravascular coagulation is an acquired acute, subacute or chronic
coagulation or thrombohaemorrhagic disorder characterized by formation of microthrombi, consumption
of coagulation factors/platelets, activation of fibrinolytic system and haemorrhage. It occurs as a
secondary complication to a variety of disorders and infectious diseases but its occurrence in tuberculosis
is rare and has not been reported.
Objective: The aims of this paper are to present a case of Disseminated Intravascular Coagulation
complicated by Acute Renal Failure in a patient…
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IntrOduction
Historically, the first case of sickle cell disease
(SCD) was reported in 1910 by a Dental Surgeon
who made blood films of one of his patients and
demonstrated red blood cells having a "slender
sickle shape' ,.1 The history of sickle cell anaemia is
a very good reminder of the importance of
supportive role of the laboratory to clinical diagnosis
and research'". The observation that sickle cell trait
may have a survival advantage against malaria was
based on the…
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ABSTRACT
Background: Unlike Chronic Myeloid Leukemia (CML) whose genetic basis (the Philadelphia
chromosome), has become a household name, that of Polycythaemia Vera and other non-leukemic
myeloproliferative diseases has not equally received wide publicity.
Aim: The aim of this paper is to review and highlight the role of JAK2 mutation in Polycythaemia Vera,
Primary Myelofibrosis and Essential Thrombocythaemia.
Methods: Literature on the subject was reviewed using manual library search, articles in journals, internet
search and conference abstracts.
Results: JAK2 mutation plays…
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Summary
Sickle cell anaemia (SCA) complications namely stroke, osteomyelitis, retinopathy,
pulmonary embolism, renal failure, chronic leg ulcers, cholelithiasis, acute chest syndrome,
avascular necrosis (AVN) of the head of femur, and others, affect virtually all systems of the
body. The prevalence and pattern of the complications of this disorder in south-south Nigeria
had not been documented. The objective of the study was to detect and analyze frequency of
occurrence of the different types of complications seen in adult SCA patients in…
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Abstract
Background: South-South geopolitical region of Nigeria is a region rich with oil exploration activities. The people in this region
are exposed to petroleum products which is one of the factors associated with leukaemia. There are limited data on leukaemia
among these people. This study sought to document the clinical and laboratory characteristics of patients with leukaemia from
this region. Materials and methods: One hundred and sixty-three (163) case notes of patients from this region with the diagnosis
of leukaemia…
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Abstract
Background: Sickle cell disease is a chronic debilitating condition. Nigeria has the largest pool of the sickle
cell gene in the world. Three to five million people are affected in Nigeria. Knowledge of the disease may help
in reducing the national prevalence.
Objective: To determine the level of awareness of sickle cell disease in a typical rural community of Delta State.
Method: Structured researcher-administered questionnaires were used to collect information from residents of
Akoku-Uno community of Delta state.
Resuts:…
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Abstract
Introduction: Haematological malignancies (HM) are malignant disorders involving the haemopoietic system. Oxidative stress has been implicated in the development and evolution of these disorders. To measure total antioxidant capacity (TAC) in patients with HM and to determine if any, the relationship between TAC and total lipid in these patients.
Presentation of the case: This is a multicentre cross sectional study. Patients were sampled with self administered questionnaire that documented their biodata and the various types of haematological malignancies they…
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Abstract
Background: Blood and blood components transfusion is a very important component of medical practice and
patients’care. However, this wonderful therapeutic tool is associated with some disadvantages namely adverse
transfusion reactions which in some cases lead to fatal consequences defeating the essence of its usage.
Objectives: This study aims to establish the modes of presentations (signs and symptoms) of blood transfusion
reactions among recipients of blood in Delsuth, Oghara.
Methodology: Records of our patients who were reported to have blood…
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ABSTRACT
Background: Blood transfusion is a very essential part of medical practice. However, blood and
blood component transfusions are associated with some adverse transfusion reactions. Some of
these reactions can lead to loss of patients’ lives and hence defeating the essence of blood usage
in saving lives.
Objectives: This study aims to establish those factors promoting and increasing the susceptibility
of patients for adverse transfusion reactions.
Methodology: Two-year records (July 2014-June 2016) of our patients reported to have blood
transfusion…
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ABSTRACT
Background: The demand to study medicine in Nigeria is very high thereby putting lots of pressure
to the University authorities because of inadequate space and provision to accommodate the large
number of applicants.
Objective: The aim of this study was to determine the factors motivating students and influencing
their desire to study medicine and proffer solutions to reduce the population of applicants to
medical schools.
Methodology: Self-administered questionnaires were used to collect information from 311 medical
students of Delta…
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Abstract
Objective(s): The present study was designed to provide additional information on some hematological and
biochemical changes associated with blood transfusion in sickle cell anemia (SCA) patients.
Materials and methods: A total of 86 subjects (aged between 20 and 40 years) were randomly studied. Among
these were 30 multi-transfused SCA (? 3 units of blood per year), 30 rarely transfused SCA (year) and 26 apparently healthy individuals. The blood samples collected in EDTA were used for packed cell
volume, haemoglobin…
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ABSTRACT
Background: There is continuous rise in haematology and haemato-oncology cases in Nigeria.
Unfortunately, there is inadequate number of haematologists to care for these rising cases despite
the high number of medical doctors being churned out by over twenty medical schools in Nigeria.
Object: The aim of this study is to find out the preference rate of Haematology among medical
students in a typical Nigerian medical school.
Methodology: Questionnaires were used to collect data from medical students who met the READ MORE Download Staff Profile

BACKGROUND
Drug-induced thrombocytopenia (DITP), which also includes
thrombocytopenia induced by beverages, foods, and herbal remedies, is
an important clinical problem for haematologists. Drug-induced
thrombocytopenia is often misdiagnosed as immune thrombocytopenic
purpura with resulting inappropriate treatment. Immune thrombocytopenic
purpura (ITP) is a clinical disorder that leads to easy bruising (purpura),
excessive bleeding or extravasation of blood from capillaries into skin and
mucous membranes (petechiae). The bleeding tendency is due to decreased
number of circulating platelets (thrombocytopenia). There is production of
antibodies…
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My role as a blood transfusion coordinator in a
rural new teaching hospital and distribution of
ABO and RHO blood groups among patients
attending Delta State University Teaching
Hospital, Oghara during the period of July 2010
to March 2011

ABSTRACT:
The abuse of chemicals particularly psychoactive substances has been on the increase amongst the youth
populace to the extent of becoming a front burner and top category public health concern in many developing
nations of Africa, hence the aim of this study to evaluate the use of psychoactive substance and its risk factors
among secondary school students in Port Harcourt LGA of Rivers State, so as to establish the prevalence rate of
the use of the substances among the…
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The anxiolytic effect of the leaves of water lily was investigated using mice as experimental
animals. Thirty (30) were mice randomly divided into group 1, 2 and 3. Before the neurobehavioral
parameters were assessed, the LD50 and the phytochemical screening of the leaves of the plant
were determined. The open field maze and the transition box apparatus were used to determine
the level of fear and anxiety related behaviors in mice. In the open field arena, the grooming
frequency was…
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Abstract
Ficus thonningii plant has been reported to be used for the treatment of various ailments, such as stomach ache, pain diarrhea, etc. Therefore, the present study was carried out to investigate its effect on exploratory/locomotor activities of the ethanol extract of the leaves of the plant. Exploration/locomotor behavior were assessed using the open field maze and the light/dark transition box tests. Animals were divided into three groups containing 10 mice each. Group A served as the control which was…
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ABSTRACT
Since prehistoric times, man has relied on herbal plants as source of medicine in curing various ailments. This
study was carried out to assess the anti- anxiety-like effect of the ethanol extract of Wild fig (Ficus thonningii) in
Swiss white (CD-1) mice. Thirty Swiss mice were randomly divided into three groups (1-3), n=10). Group 1
(control) was administered normal rat fed and saline, while group 2(low dose) and group 3(high dose) were
administered 10mg/kg w/w and 20mg/kg w/w of…
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Abstract
Excess body fat deposition is known to be unhealthy. There have been several
discourses on defined anthropometric indices for the assessment and a better
prediction of obesity in pregnant women. This is because certain cut-off values
relating to obesity in pregnant subjects are highly influenced by age, sex, ethnicity
and trimesters of pregnancy. This study is aimed at investigating the use of two
basic anthropometric indices to measure obesity and evaluate its prevalence in
the different trimesters of pregnancy.…
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ABSTRACT
Background: The morphology of an individual‘s external ear and its
dimensions vary amongst persons to the point that the right and left ears
differ.
Aims: This study is aimed at establishing the anatomical variation in the
auricular structure of the students of University of Port Harcourt, Nigeria.
Methods: The study utilizes a total of 200 students, 101 male and 99 female
subjects within the age range of 16-30 years. Total ear length and breadth of
both ears were measured…
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Abstract
Original Article
Introduction
Every individual needs a certain amount of body fat for
energy, heat insulation, and shock absorption. However,
excessive deposition of fat in the body, which is usually
referred to as overweight or obesity, has been found to be
medically deleterious to the body. Overweight specifically
refers to an excess body weight compared to set standards,
while obesity is to have an abnormally high proportion of
total body fat.[1]
Obesity is a medical condition in which excess…
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ABSTRACT
The aim of this present study is to investigate the effect of repeated administration of 5-Hydroxytryptophan diet (5-HTP)
on learning and memory using CD-1 mice as experimental animals. Twenty male (20) mice were randomly assigned into
two groups of ten mice each, namely; Control and 5-Hydroxytryptophan diet (15%w/w) groups. Feeding lasted for 28
days, during which there were daily measurements of food intake, water intake and body weight changes. Thereafter, the
Morris water maze task was used to assess…
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ABSTRACT
Manihot esculenta Crantz leaves have been used against many disorders, such as rheumatism, fever, headache,
diarrhea, and loss of appetite. Cassava leaves reportedly also possess anti-hemorrhoid, anti-inflammatory, and
antimicrobial activity. The aim is to investigate the effect of aqueous extract of Manihot esculenta and piroxicam
co-administration for induced gastro-toxicity in male wistar rats and thus determine histo-morphologic changes in
the stomach due to piroxicam-mediated toxicity. The leaves of Manihot esculenta leaves were collected and dried
for two weeks at…
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Background: Telfairia occidentalis seed is a multipurpose
plant with many attributes and considerable therapeutic
potentials. Carbon Tetrachloride is one of the oldest and
most widely used toxins for experimental induction of liver
fibrosis in laboratory animals. The Liver is usually the organ
to receive the effect of this chemical thereby causing
hepatotoxicity, simply because of its method of metabolism,
as well as carrying out the first pass effect by metabolizing
endogenous and exogenous substances hence its
consideration.
Aim: The aim…
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Abstract
The use of Mucunaflagellipes in recent time has been on the increase as a result of its speculated therapeutic effect mostly on the
protein level of the body. And owing to the fact that there are no detailed reports on Mucunaflagellipes on its effect on neurobehavioral
parameters, this work is therefore intended to investigate the possible effects of this herb on the exploratory behavior and body
weight in Swiss white mice. Twenty (20) mice of mixed sex were randomly…
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Abstract: It was therefore the aim of this study to find out whether long term consumption of cooked and uncooked
beans (cowpea) diet has effects on some neurobehavioral parameters such as anxiety and fear using Swiss white mice as
experimental animals, since cowpea contain serotonin and its precursor 5-Hydroxytryptophan which have
neurobehavioral effects. Forty (40) Swiss mice were randomly assigned into four groups. Control (group A) were fed
normal rodent chow, cooked beans (group B) received cooked beans diet (50%…
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ABSTRACT Objectives: Study was carried out to determine the incidence of male infertility in Medical Art Center, Maryland Ikeja Lagos, Western. Nigeria. Method: The specimens were collected and analyzed in the andrology laboratory. The standard method of masturbation after 3-5 days of prior abstinence from sex before sample collection was applied. The samples were examined for semen volume, morphology, sperm motility and count. Result: The semen samples of 263 (two hundred and sixty three) males attending infertility clinic, aged between…
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ABSTRACT
The purpose of the present study was to evaluate the effects of ethanolic leaf extract of Chrysophyllum albidum on hormones and sperm analysis of laboratory rats. Fifteen male rats weighing 230-250g were completely randomised into three groups: A-C. Animals in Group A (control) were orally administered with 0.5ml of distilled water once daily for 21 days while those in Groups B and C, received 500 and 1000mg/kg body weight of the extract respectively), and effect of the treatment on…
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Abstract:
Purpose: The ethanolic root bark of Chrysophyllum albidum were evaluated for their effect on antioxidant
enzymes such as superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (malondialdehyde)
activities in rats.
Methods: Eighteen male Wister rats weighing 100-200g were divided into three groups of six animals each.
Two treated groups received a daily dose of ethanolic root bark of Chrysophyllum albidum at 100mg/kg and
200mg/kg body weight respectively via gastric gavage, while equal volume of normal saline was administered
to…
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ABSTRACT
Potassium bromate (KBrO3) is classified as mutagenic and carcinogenic although used in food and
cosmetics industries, and also found in drinking water as a by-product of disinfection. Industrial
pollution of drinking water and its ability to cross the blood-brain barrier lead to the investigation of its
effect on the cerebral cortex. Twenty adult Wistar rats with average weight of 200 g were divided into
four groups designated as ‘A’ for the control group, and ‘B, C and D’ for…
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Objective: The aim of this study was to determine the effect of lime juice on the fetal parameters of Sprague-Dawley rats
Materials and Methods: Forty adult female Sprague-Dawley (SD) rats were used. They were randomly divided into 2 groups (I and II) of 10 rats each. The estrous cycles of the rats were studied for the first 16 days to establish cyclicity. The rats were mated with male SD rats of proven fertility on the estrous day (heat period) of…
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Summary: The present study was conducted to investigate the antifertility activity of the ethanol root bark extract of Chrysophyllum albidum on sperm parameter and hormonal levels in rats. Eighteen male rats were divided into three groups of six animals each. The first group (A) received distilled water and served as control. The second and third group (B & C) of animals were administered the ethanol root bark extract daily at 100mg/kg body weight and 200mg/kg decrease in the caudal epididymal…
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Abstract
Objective: The study was aimed at investigating the hypoglycemic, antioxidant and Hepatoprotective
effects of Chrysophyllum albidum in diabetes induced male Wistar rats. Methods: Ethanol root bark
extract was administered to thirty rats of six groups A, B, C, D, E and F of five rats each, weighing
between 150-170g. Diabetes was induced in Groups B, C, D, E and F using a single intraperitoneal
injection of 140mg/kg of Alloxan after an overnight fast. Group A served as the normal…
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ABSTRACT
Despite important progress in the management of diabetes using synthetic drugs, many traditional plant treatments
are still being used throughout the world.
The goal of this study was to investigate the effects of ethanol leaf extract of Chrysophyllum albidum on the
histology of the pancreas of STZ-induced diabetic rats. Thirty rats divided into six groups (n=5). Groups I and II
received only normal saline; group III received 2 mg/kg of glibenclamide; groups IV, V and VI received 125, 250, READ MORE Download Staff Profile

Abstract
Background Stroke is a very troubling illness as it not only disables its victim, but also kills most of them outright. Its rate is increasing in the developing countries and this drains their finances. As a result many seek management of their condition in herbal homes. But of recent there is a preference to herbal medicine by most stroke survivors, irrespective of social status. This is a new phenomenon.
Objective The main objective of this study was to assess…
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Antioxidant, hypolipidemic and Hypoglycemic Effect of Ethanol Leaf Extract of Chrysophyllum albidum on Streptozotocin- Induced Diabetic Rats.