Aim: This study aim to evaluate the modulatory ef fect of ethanolic leaf extract of  Annona muricata against dimethylnitrosamine (DMN) -induced hepatic toxicity in rats.    

Methodology:  Twenty- four (24) male albino rats divided into four (4) groups of six (6) rats each were used for the study. Group 1 served  as control and was untreated, group 2 and 3 were pre -treated with 400  mg/kg Annona muricata  for one week while group 3 and 4 each received a single oral  dose  of  20   mg/kg  DMN  after  one  week.  The  rats  were  sacrificed  48   hrs  after  DMN administration.