MODULATORY EFFECT OF ETHANOLIC LEAF EXTRACT OF ANNONA MURICATA PRE-TREATMENT ON LIVER DAMAGE INDUCED BY DIMETHYLNITROSAMINE (DMN ) IN RATS
Prof Usunobun Usunomena and Okolie P. Ngozi and Eze G. Ikechi (Published 2015)
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Aim: This study aim to evaluate the modulatory ef fect of ethanolic leaf extract of Annona muricata against dimethylnitrosamine (DMN) -induced hepatic toxicity in rats.
Methodology: Twenty- four (24) male albino rats divided into four (4) groups of six (6) rats each were used for the study. Group 1 served as control and was untreated, group 2 and 3 were pre -treated with 400 mg/kg Annona muricata for one week while group 3 and 4 each received a single oral dose of 20 mg/kg DMN after one week. The rats were sacrificed 48 hrs after DMN administration.
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 602.24 KB|
|Keywords:||Annona muricata; dimethylnitrosamine ; hepatic; ethanol; necrosis.|
|Field of Study:||Biochemistry|
|Uploaded By:||Imarhiagbe Odoligie|
|Date Added:||22 Nov 2017 12:14pm|
|Last Modified:||28 Nov 2017|
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