Objective: Chromolaena odorata is  used  in  traditional  medicine  in  Nigeria  to  remedy  malaria,
abdominal  and  cervical  pain and as  local  antiseptic  agent for  wound. This  study  was  carried  out  to  identify
bioactive  agents  and  minerals  as  well  as  in  vitro  antioxidant  activities  of  Chromolaena  odorata  leaves.
Methods: Phytochemical screening was carried out using standard procedure; mineral analysis was carried out
using Atomic Absorption spectrophotometer while reducing power and DPPH radical scavenging activity were
determined  spectrophotometrically. Results:  Phytochemical  screening  showed the  presence  of  flavonoids,
saponins,  alkaloids,  tannins  etc.  Mineral  analysis  showed  the  richness  of  Chromolaena  odorata  leaves  in
calcium (487.40mg/100g),  sodium (44.22mg/100g),  potassium (96.91mg/100g),  magnesium (116.70mg/100g),
zinc (3.77mg/100g), iron (67.71mg/100g), phosphate (143.15mg/100g) etc. The results on reducing power and
DPPH radical scavenging activity indicates that at higher concentration, the plants ability to scavenge DPPH
radical and  reducing  power  ability increases. Conclusion: Chromolaena  odorata  leaves  have  potential  for
development of therapeutically active compounds which could serve as precursors for the design of potent and
safe drugs.