PLASMA INTERFERON-GAMMA AND IL-4, IMMUNOGLOBULIN CLASSES AND NITRIC OXIDE IN NIGERIANS WITH ACUTE LEUKAEMIA 2018/2019

Dr Rahamon Sheu Kadiri and Akinloye Oluyemi1, Adegbenro Micheal1, Olaniyi John A2, Rahamon Sheu K3, Anifowose Agnes I1, Awosika Emmanuel O1 and Arinola Ganiyu O3*   (Published 2018)

Dr Sheu Kadiri
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Abstract

ABSTRACT
Acute leukaemia are usually rapidly progressive with death often occurring in a few weeks to a few months in untreated patients as a result of abnormal hematopoietic function as well as impaired immune response. The risk of relapse which remains in 20% of patients in remission calls for more research on acute leukaemia. This study therefore, evaluated the plasma levels of nitric oxide (NO), interleukin-4 (IL-4), interferon-gamma (IFN-?) and immunoglobulin classes (IgA, IgG, IgM, IgE) in twenty-five (25) patients with acute leukaemia (AL) and twenty-five (25) apparently healthy controls. The mean levels of plasma IgA, IgG and IgM were not significantly elevated in leukaemia patients compared with control. However, the mean plasma levels of IgE, NO, IL-4 and IFN-? were significantly elevated in leukaemia patients compared with controls. It could therefore be concluded from this study that humoural immunity is not depressed in acute leukaemia patients.


Item Type: Journal article(non-copyrighted)
Format: PDF document,   719.79 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: BIOCHEMISTRY
Department: Natural Science
Field of Study: Biochemistry
Uploaded By: Uwaifo Ferdinand
Date Added: 10 Mar 2019 12:24am
Last Modified: 09 Mar 2019
Journal URL: https://www.edouniversity.edu.ng/oer/journal/plasma_interferon-gamma_and_il-4_immunoglobulin_classes_and_nitric_oxide_in_nigerians_with_acute_leukaemia_20182019


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