The present study was conducted to evaluate the protective role of ethanolic leaf extract of Annona
muricata  on dimethylnitrosamine  (DMN)-induced  hepatotoxicity  in  rat  model.  DMN  administered  rats  (single
dose orally, 12 mg/kg; on day 8) were pretreated with ethanolic leaf extract of Annona muricata (400 mg / kg
body  weight)  for  7  days  and  sacrificed  48hrs  after  DMN  intoxication.  Results  showed  that  DMN  caused  a
marked  rise  in  serum  alanine  aminotransferase  (ALT),  total  cholesterol  (TC),  as  well  as  marked  decrease  in
serum  total  protein  (TP),  globulin, albumin  (ALB),  PCV,  WBC,  RBC,  Hemoglobin  and  platelet compared  to
controls. However pretreatment with Annona muricata ethanolic leaf extract produced a significant decrease in
the  ALT  and  total  cholesterol  level  and  an  increase  in  total  protein,  globulin, albumin and  hematological
parameters compared to DMN alone group. Taken these data together, it can be concluded that natural plant
components  such  as  Annona  muricata  leaves  could  protect  the  liver  against  dimethylnitrosamine  (DMN)-induced liver toxicity