RAISED IGE LEVEL IN NIGERIAN SICKLE CELL DISEASE CHILDREN: IMPLICATION FOR SEVERITY OF ALLERGIC REACTIONS

Dr Rahamon Sheu Kadiri and Ajani FO, Adelakun A, Ogunleye TD, Disu E, Olaniyi J, Arinola OG   (Published 2013)

Dr Sheu Kadiri
See Profile Page

Abstract

Ajani FO, Adelakun A, Ogunleye TD, Disu E, Olaniyi J, Rahamon SK, Arinola OG. Raised IgE level in Nigerian Sickle Cell Disease Children: Implication for severity of allergic reactions. J Appl Hematol 2013; 4 (4):149-152.

 

 

ABSTRACT

Background: Susceptibility of sickle cell disease subjects to various infectious agents is on the increase, but information relating SCD to allergic condition is scarce. Hence, assessment of immunoglobulin status in SCD children may provide useful information to improve management of SCD children.

Objectives: To determine the levels of immunoglobulin classes (IgG, IgA, IgM, and IgE) in Nigerian HbSS children below 5 years of age compared with sex- and age-matched HbAA children.

Materials and Methods: Blood samples were collected from a total of 45 children less than 5 years of age who were recruited into the study as follows: 26 HbSS and 19 HbAA subjects for the estimation of serum immunoglobulin levels using enzyme-linked immunosorbent assay (ELISA) techniques and determination of genotype using electrophoresis technique.

Results: IgG concentration was nonsignificantly higher (P = 0.997) in HbSS children (1022.56 ± 148.97 ng/ml) compared to HbAA children (933.68 ± 106.10 ng/ml). IgA (P = 0.906) and IgM (P = 0.986) concentrations were nonsignificantly lower in HbSS children (255.07 ± 133.71 ng/ml) compared to HbAA children. IgE was signi?cantly higher (P = 0.000***) in HbSS (108.67 ± 69.22 IU/ml) compared to HbAA (24.51 ± 17.58 IU/ml) children.

Conclusion: SCD children in steady state have adequate levels of Ig classes. Non-speci?c elevation of IgE levels may be a factor of in?ammatory response in SCD children, and this may be proposed for reduced allergic reaction among SCD children.


Item Type: Journal article(non-copyrighted)
Format: Word document,   15.89 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: Raised IgE level
Department: Natural Science
Field of Study: Biochemistry
Uploaded By: Uddin Osemengbe Oyaimare
Date Added: 02 Nov 2017 11:40am
Last Modified: 02 Nov 2017
Journal URL: https://www.edouniversity.edu.ng/oer/journal/raised_ige_level_in_nigerian_sickle_cell_disease_children_implication_for_severity_of_allergic_reactions


Google Docs     Print     Download