Dr Olaniyan Olugbemi Tope and B. J. Dare1*, F. Oyeniyi   (Published 2019)

Dr Olugbemi Tope
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Spermatogenesis is an extremely active replicative process capable of generating
approximately 1000 sperms a second with correspondingly high rates of mitochondrial
oxygen consumption by the germinal epithelium. This process generates reactive oxygen
species (ROS) through reactions with drugs and environmental toxins, or when the level of
antioxidants is diminished results in oxidative stress. Excessive production of free radicals
or ROS can damage sperm, testes and can cause serious chemical damage to
biomolecules (DNA, proteins, and unsaturated lipids) which ultimately lead to cell death
and cause infertility. The cell has several protective mechanisms that minimize the toxic
potential of these reactive oxygen species. These include the low oxygen tension in the
tissue and also the elaborate array of antioxidant enzymes and free radical scavengers it
contains; to ensure that the spermatogenic and steroidogenic functions of this organ are
not impacted by oxidative stress.

Item Type: Journal article(non-copyrighted)
Format: PDF document,   424.39 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: physiology
Department: Medicine and Surgery
Field of Study: Health and Society
Uploaded By: Uwaifo Ferdinand
Date Added: 06 Feb 2019 2:44pm
Last Modified: 06 Feb 2019
Journal URL:

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