Dr Olaniyan Olugbemi Tope and Adeoye Oyetunji Oyewopo, Joseph Babatunde Dare1, Olugbemi Tope Olaniyan2, Akunna Godson Gabriel3   (Published 2019)

Dr Olugbemi Tope
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Introduction: Volatile organic compounds (VOCs) in paint are considered harmful to the
environment, especially for people who work with them on a regular basis. Aim: In this study,
we investigated the effect of VOCs in gloss paint, emulsion, and thinner on the testes of male
Wistar rats. Materials and Methods: Twenty adult Wistar rats (100–200 g) were assigned to
four (4) groups (A–D) of five rats each. Groups A (thinner), B (emulsion paint), and C (gloss
paint) were exposed to fumes from one coating of an improvised chamber for 1 h daily for 21
days while Group D was the control group exposed to fresh air. The rats were exposed to the
test chemicals using an improvised chamber of a carton with dimensions 37 cm × 25 cm × 25
cm and had a cross?ventilation (aeration) with six triangular holes of base 4 cm with spaces
approximately 1 cm apart and 2 cm on each side. The rats were usually brought out of the
animal house, placed in the carton coated with their respective paints for a period of 1 h daily,
and then returned to the animal house under normal standard room temperature for 21 days.
The rats were sacrificed 24 h after the last exposure day, by cervical dislocation. Results: In
this study, the t?test for the body weight of the animal showed no statistical significance (P >
0.05). There was a significant decrease in sperm count and motility and deranged testicular
profile in the groups exposed to nitrocellulose thinner, emulsion paint, and gloss paint. The
follicle?stimulating hormone (FSH) values increased from those exposed to gloss paint, control
thinner, and emulsion. The luteinizing hormone (LH) values increased from emulsion, control,
gloss, and thinner. The testosterone (TT) values increased from gloss, emulsion, control, and
thinner. Conclusion: We concluded that the exposure to VOCs present in paint has a
deleterious effect on the reproductive potentials of an adult male Wistar rat.
Adeoye Oyetunji Oyewopo,
Joseph Babatunde Dare1,
Olugbemi Tope Olaniyan2,
Akunna Godson Gabriel3
Department of Anatomy, University of
Ilorin, Ilorin, Departments of 1Anatomy
and 2Physiology, Bingham University,
Karu, Nasarawa, 3Department of
Anatomy, Federal University
Ndufu?Alike Ikwo, Ebonyi, Nigeria
Address for correspondence:
Dr. Adeoye Oyetunji Oyewopo,
Department of Anatomy, University of
Ilorin, Ilorin, Nigeria.

Item Type: Journal article(non-copyrighted)
Format: PDF document,   1.11 MB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: physiology
Department: Medicine and Surgery
Field of Study: Health and Society
Uploaded By: Uwaifo Ferdinand
Date Added: 06 Feb 2019 3:07pm
Last Modified: 06 Feb 2019
Journal URL:

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