SERUM COPEPTIN AND CORTISOL DO NOT ACCURATELY PREDICT SICKLE CELL ANAEMIA VASO-OCCLUSIVE CRISIS AS C-REACTIVE PROTEIN
Dr Rahamon Sheu Kadiri and Akinlade KS, Atere AD, Olaniyi JA, Adewale CO (Published 2013)
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Objective: This study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin and cortisol in individuals with sickle cell anaemia (SCA).
Methods: Sixty consecutive SCA subjects (18–40 years) comprising 30 subjects in the steady state and 30 subjects in vasoocclusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy individuals with HbAA genotype served as controls. ELISA was used for the determination of serum levels of copeptin, CRP and cortisol. Data obtained were statistically analyzed using the Student’s t-test and Mann Whitney U as appropriate and P
Conclusion: It could be concluded that C-reactive protein has a superior diagnostic performance for vaso-occlusive crisis in individuals with sickle cell anaemia and that C-reactive protein, cortisol and copeptin are not good prognostic markers in SCA subjects in vaso-occlusive crisis.
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 800.04 KB|
|Field of Study:||Biochemistry|
|Uploaded By:||Uddin Osemengbe Oyaimare|
|Date Added:||02 Nov 2017 11:38am|
|Last Modified:||22 Nov 2017|
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