Dr Rahamon Sheu Kadiri and Akinlade KS, Fagbomedo FO, Makanjuola VA, Ampitan AB   (Published 2014)

Dr Sheu Kadiri
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Akinlade KS, Fagbomedo FO, Rahamon SK, Makanjuola VA, Ampitan AB. Serum copeptin and its diagnostic performance in schizophrenia. Afr J Med Med Sci 2014; 43: 259-264






Inappropriate arginine vasopressin (AVP) secretion has been reported in schizophrenic patients. However, there is lack of information on serum level of copeptin and its diagnostic performance in schizophrenia. This study therefore, evaluated serum copeptin and its diagnostic performance in schizophrenic patients.


Sixty subjects (30.02 ± 7.17 years) with schizophrenia (19 drug naïve [DNS] and 41 schizophrenics on treatment [SOT]) and 30 healthy individuals (33.62 ± 9.05 years) with no history of schizophrenia were enrolled into this study. Schizophrenia was diagnosed using the Tenth edition of the International Classification of Diseases and Related Health Problems (ICD-10). Estimation of serum copeptin, plasma electrolytes (potassium, sodium and chloride) and uric acid was done using ELISA, Ion-Selective electrode (ISE) and enzymatic method respectively.


Copeptin was significantly higher while uric acid, potassium and sodium levels were significantly lower in patients with schizophrenia compared with controls. Similarly, copeptin was significantly higher while sodium, potassium and uric acid levels were significantly lower in DNS and SOT compared with controls. However, insignificant elevation in copeptin level and insignificant reduction in sodium, potassium, chloride and uric acid levels were observed in DNS compared with SOT. The Area under the curve (AUROC) for copeptin was 0.686 (P = 0.004).


There is elevated copeptin level in patients with schizophrenia and that copeptin levels might be a valuable tool in the diagnosis of schizophrenia.

Item Type: Journal article(non-copyrighted)
Format: Word document,   15.13 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: Serum copeptin, schizophrenia
Department: Natural Science
Field of Study: Biochemistry
Uploaded By: Uddin Osemengbe Oyaimare
Date Added: 02 Nov 2017 12:13pm
Last Modified: 02 Nov 2017
Journal URL:

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