SERUM COPEPTIN AND PREGNANCY OUTCOME IN PREECLAMPSIA
Dr Rahamon Sheu Kadiri and Akinlade KS, Adediji IO, Fawole AO, Tongo OO (Published 2015)
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Background: A number of biochemical predictors of preeclampsia have been reported, but little is known about their possible relationship with maternal and fetal outcomes. This study determined serum copeptin in pregnant women with preeclampsia and assessed its relationship with pregnancy outcomes.
Results: Copeptin was significantly elevated in preeclampsia subjects compared with controls and in SP compared with MP. Assessing the diagnostic property of copeptin for preeclampsia, the area under the curve for copeptin was 0.99. Nine (30%) and 3 (10%) of SP and MP, respectively had abruption placenta while 6 (20%), 2 (6.7%), and 1 (3.3%) still births were recorded in SP, MP, and controls, respectively. Neonates of mothers with preeclampsia had significantly lower birth weight, infant length, ponderal index, and head circumference compared with neonates of the controls. Copeptin had a significant inverse relationship with birth weight, ponderal index, head circumference, Apgar score, and infant length in neonates of mothers with preeclampsia.
Conclusion: Serum copeptin level in the third trimester could predict preeclampsia and its elevation is associated with adverse perinatal outcome.
|Item Type:||Journal article(non-copyrighted)|
|Format:||PDF document, 0.88 MB|
|Keywords:||Abruptio placenta, Apgar score, copeptin, perinatal outcome, ponderal index, preeclampsia|
|Field of Study:||Biochemistry|
|Uploaded By:||Uddin Osemengbe Oyaimare|
|Date Added:||02 Nov 2017 12:29pm|
|Last Modified:||22 Nov 2017|
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