Dr Rahamon Sheu Kadiri and Ganiyu Olatunb osun A rinola, PhD, O lajumoke Abimbola More nikeji, PhD, Kazeem Sanjo Akinwan de, MSc, Ayodele Ola soji Alade, MSc, Oluwa kemi Olateru-O lagbegi, MSc, Ponmile Emm anuel Alabi, MSc, PhD   (Published 2015)

Dr Sheu Kadiri
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BACKGROUND The prevalence of helminth infection, which is known to affect nutritional status of
the host, varies with age. The complex interplay between ages, nutrient requirements, and infection
necessitated the need to recommend micronutrient supplementation during helminth infection among
different age groups.
OBJECTIVE The aim of this study was to determine the pattern of alteration in selected micro-nutrients in pregnant women and preschool- and school-aged children with helminth infection.
METHODS We screened 245 pregnant women and 349 children for helminth infection. Of these, 17
(6.9%) pregnant women and 102 (29.2%) children (42 preschool- and 60 school-aged) had helminth
infection. Only Ascaris lumbricoides was found in pregnant women, whereas the children had A
lumbricoides, hookworm, Fasciola hepatica, and Trichuris trichiurainfections. The helminth-infected (HI)
pregnant women, preschool-aged children, and school-aged children were matched with helminth-negative (HN) pregnant women (n ¼ 21), preschool-aged children (n ¼ 42), and school-aged children
(n ¼ 50) who served as controls. Venous blood samples were obtained and analyzed for iron (Fe), zinc
(Zn), selenium (Se), and vitamins A and C. Statistical analysis was done using Student ’s t test, and
P < 0.05 was considered statistically signi ficant.
FINDINGS Serum levels of Fe, Zn, and Se were signi fi cantly lower in HI pregnant women than HN
pregnant women. In preschool-aged children, serum levels of Fe, Zn, and vitamin A were signifi cantly
lower in the HI than in the HN group. Similarly, serum levels of Zn and vitamin A were signi ficantly lower
in HI school-aged children than in the HN group. However, serum levels of Se were signi ficantly higher in
HI children (both age groups) than in the corresponding HN group.
CONCLUSION Helminth infection alters different types of micronutrients in children and pregnant
women. Results from the present study therefore suggest monitoring Fe, Zn, or vitamin A supple-mentation with an anti-helminthic regimen

Item Type: Journal article(non-copyrighted)
Format: PDF document,   128.74 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: children, essential minerals, helminth infection, pregnant women, supplementation, vitamins
Department: Natural Science
Field of Study: Biochemistry
Uploaded By: Imarhiagbe Odoligie
Date Added: 22 Nov 2017 9:25am
Last Modified: 22 Nov 2017
Journal URL:

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