Dr Olaniyan Olugbemi Tope and Meraiyebu Ajibola1*, Olugbemi Olaniyan1, Oshimakinde Abiola1, A. Seriki Samuel1 and Okere Shekins2   (Published 2019)

Dr Olugbemi Tope
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Aim: This study was carried out to investigate the role of coconut oil on
pentylenetetrazole (PTZ) induced convulsant activity in Wistar rats using the laboratory
model. Convulsant activity was achieved by injection of PTZ.
Study Design: The rats were divided into five groups. Group 1 served as control and
received distilled water orally. Group2 was a reference group and received only PTZ. The
remaining three groups (3, 4 and 5) were test groups and rats were given oral
administration of coconut oil at doses of 2, 4 and 5.3 ml/kg for 21 days.
Methodology: 25 rats weighing between 125 and 200g were used. 30 minutes after the
last administration of coconut oil after 21 days, a convulsive dose of PTZ was given
intraperitoneally. Electroencephalogram (EEG) readings of the rats were then taken using
an EEG machine and electrodes placed on the head of the rats recorded the waves
produced on the scalp of the rats. The frequencies of the waves recorded were analyzed
and compared for all groups.
*Corresponding author: Email:;
British Journal of Pharmaceutical Research, 4(7): …………, 2014
Result: The frequency of EEG readings produced during convulsion that was caused by
the PTZ in the rats were reduced for the rats that received coconut oil. There was a
significant decrease in the mean frequency of EEG of rats that received 2, 4 and 5.3 ml/kg
coconut oil ( which had frequencies of 13Hz, 14.6Hz and 14. 4Hz, respectively) when
compared with the reference group that received only PTZ which had a mean frequency
of 16Hz. Coconut oil significantly reduced the frequency produced by PTZ. The result also
shows that the lower dose group had the most appreciable decline in convulsive activity
returning the frequency of electroencephalogram waves recorded to 13Hz same as the
control group.
Conclusion: The result suggests that coconut oil given at a moderate dose has
anticonvulsant effect and will cause an increase in weight. These findings supports
reports that ketogenic diet could help reduce convulsant activities and epileptic seizures.

Item Type: Journal article(non-copyrighted)
Format: PDF document,   777.28 KB
Copyright: Creative Commons LicenseCreative Commons license
Keywords: physiology
Department: Medicine and Surgery
Field of Study: Health and Society
Uploaded By: Uwaifo Ferdinand
Date Added: 06 Feb 2019 3:08pm
Last Modified: 06 Feb 2019
Journal URL:

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