General overview of the Course
This course covers the theoretical basis of laboratory tests of clinical significance in diagnosis
and management of diseases. Routine tests of general well being- renal function tests and liver
function tests, Introduction to pharmacological concepts, Drug administration, absorption,
distribution and receptors. Xenobiochemistry, Drug metabolism, Drug metabolizing enzymes
and drug interactions. Role of Cytochrome P450. It also covers drug design, Theories of the
mechanism of drug action. The physiological and biochemical actions of some selected drugs.
Biochemical mechanisms of drug action against parasites. Metabolic factors affecting
chemotherapeutic agents. Drug resistances and other factors affecting drug efficacy. Biochemical
basis of drug resistance.